Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Venus Sosa Iglesias, Jan Theys, Arjan J. Groot, Lydie M. O. Barbeau, Alyssa Lemmens, Ala Yaromina, Mario Losen, Ruud Houben, Ludwig Dubois, Marc Vooijs*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number460
Number of pages13
JournalFrontiers in Oncology
Volume8
DOIs
Publication statusPublished - 7 Nov 2018

Keywords

  • non-small cell lung cancer
  • chemotherapy
  • targeted agents
  • radiation
  • NOTCH/gamma-secretase inhibitor
  • multicellular tumor spheroids
  • ANAPLASTIC LYMPHOMA KINASE
  • NOTCH SIGNALING PATHWAY
  • TUMOR MICROENVIRONMENT
  • OVERCOME RESISTANCE
  • TARGETED THERAPIES
  • DRUG-RESISTANCE
  • BREAST-CANCER
  • ADENOCARCINOMA
  • CARCINOMA
  • SURVIVAL

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