TY - JOUR
T1 - Synergistic effect of low K and D vitamin status on arterial stiffness in a general population
AU - Mayer, Otto
AU - Seidlerova, Jitka
AU - Wohlfahrt, Peter
AU - Filipovsky, Jan
AU - Cifkova, Renata
AU - Cerna, Vaclava
AU - Kucerova, Alena
AU - Pesta, Martin
AU - Fuchsova, Radka
AU - Topolcan, Ondrej
AU - Jardon, Kelly M. C.
AU - Drummen, Nadja E. A.
AU - Vermeer, Cees
PY - 2017/8
Y1 - 2017/8
N2 - Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix 1,1-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [13-coefficient(S.E.M.) = 13.91(4.87); P=.0041 and 25 -OH -D3 [0.624(0.28); P=.0271. In a further analysis, we divided subjects according to dp-ucMGP and 25 -0H -D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25 -OH -D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dpucMGP-plus top quartile of 25 -0H -D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P
AB - Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix 1,1-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. In a subsample of 431 subjects without chronic disease or pharmacotherapy, we detected rs2228570 polymorphism for the vitamin D receptor. After adjustment for confounders, aPWV was independently associated with both factors: dp-ucMGP [13-coefficient(S.E.M.) = 13.91(4.87); P=.0041 and 25 -OH -D3 [0.624(0.28); P=.0271. In a further analysis, we divided subjects according to dp-ucMGP and 25 -0H -D3 quartiles, resulting in 16 subgroups. The highest aPWV had subjects in the top quartile of dp-ucMGP plus bottom quartile of 25 -OH -D3 (i.e., in those with insufficient status of both vitamin K and vitamin D), while the lowest aPVW had subjects in the bottom quartile of dpucMGP-plus top quartile of 25 -0H -D3 [9.8 (SD2.6) versus 6.6 (SD1.6) m/s; P
KW - Vitamin K
KW - Vitamin D
KW - MGP
KW - gamma-Carboxyglutamate
KW - 25-Hydroxyvitamin D-3
KW - Aortic pulse wave velocity
KW - rs2228570 genotype
KW - MATRIX GLA-PROTEIN
KW - GAMMA-CARBOXYGLUTAMIC ACID
KW - 25-HYDROXYVITAMIN D LEVEL
KW - ALL-CAUSE MORTALITY
KW - VASCULAR CALCIFICATION
KW - CARDIOVASCULAR-DISEASE
KW - OSTEOGENIC REGULATION
KW - POSTMENOPAUSAL WOMEN
KW - RAT AORTA
KW - ELASTIN
U2 - 10.1016/j.jnutbio.2017.04.010
DO - 10.1016/j.jnutbio.2017.04.010
M3 - Article
C2 - 28486172
SN - 0955-2863
VL - 46
SP - 83
EP - 89
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
ER -