Symptoms, the GerdQ score and patients' characteristics do not predict gastroesophageal reflux disease in patients with proton-pump-inhibitor- refractory reflux symptoms-results from a large prospective database

Joachim Labenz, Merlissa Menzel, Oliver Hirsch, Matthias Mueller, Christian Labenz, Charles Christian Adarkwah*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background. The number of patients with proton pump inhibitor (PPI)-refractory reflux symptoms is underestimated since many patients resign after an unsuccessful therapy attempt. Thus, it would be useful having a non-invasive tool that can help identify true gastroesophageal reflux disease (GERD) patients in order to manage them early and properly. The GerdQ is a validated tool developed for this purpose but its applicability in PPI-refractory patients has not yet been investigated. Our aim was to investigate if reflux symptoms per se, the GerdQ and patients characteristics are suitable for non-invasive diagnosis of GERD in patients with PPI refractory reflux symptoms.Methods. A total of 500 patients from a prospectively recorded data base with PPI-refractory reflux symptoms were retrospectively analyzed. All patients received comprehensive diagnostic workup including EGD, pH-impedance measurement and manometry. GERD was diagnosed according to the recent Lyon consensus.Results. Of all patients enrolled in the study, 280 (56%) finally fulfilled the criteria for objectively verified GERD according to the Lyon consensus. There were no significant differences in age and gender between the patients with and without GERD, whereas the body mass index was significantly higher in the group with verified GERD, but the discriminative value was low (Welch-Test, p < .001, Cohen's d = 0.39). Furthermore, there were no significant differences in the GerdQ values between the two groups. A GerdQ cutoff value >= 9 resulted in a sensitivity of 43% and specificity of 57% with a positive predictive value of 56% and a negative predictive value of 44%.Conclusion. Based on our study, neither symptoms and the GerdQ score nor patients' characteristics are appropriate tools to distinguish between GERD and other causes for reflux symptoms in patients with PPI-refractory reflux symptoms.
Original languageEnglish
Article numbere14802
Number of pages15
JournalPEERJ
Volume11
Issue number1
DOIs
Publication statusPublished - 21 Feb 2023

Keywords

  • GerdQ questionnaire
  • PPI therapy
  • Reflux disease
  • Persistent symptoms
  • ENDOSCOPIC ASSESSMENT
  • RATING-SCALE
  • QUESTIONNAIRE
  • VALIDATION
  • DIAGNOSIS
  • MANAGEMENT
  • ACCURACY
  • CLASSIFICATION
  • ESOPHAGITIS
  • TRIAL

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