Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

Marc H. Jansen*, Sophie E. Veldhuijzen van Zanten, Esther Sanchez Aliaga, Martijn W. Heymans, Monika Warmuth-Metz, Darren Hargrave, Erica J. van der Hoeven, Corrie E. Gidding, Eveline S. de Bont, Omid S. Eshghi, Roel Reddingius, Cache M. Peeters, Antoinette Y. N. Schouten-van Meeteren, Rob H. J. Gooskens, Bernd Granzen, Gabriel M. Paardekooper, Geert O. Janssens, David P. Noske, Frederik Barkhof, Christof M. KrammW. Peter Vandertop, Gertjan J. Kaspers, Dennis G. van Vuurden

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

76 Citations (Web of Science)

Abstract

Background. Although diffuse intrinsic pontine glioma (DIPG) carries the worst prognosis of all pediatric brain tumors, studies on prognostic factors in DIPG are sparse. To control for confounding variables in DIPG studies, which generally include relatively small patient numbers, a survival prediction tool is needed. Methods. A multicenter retrospective cohort study was performed in the Netherlands, the UK, and Germany with central review of clinical data and MRI scans of children with DIPG. Cox proportional hazards with backward regression was used to select prognostic variables (P<.05) to predict the accumulated 12-month risk of death. These predictors were transformed into a practical risk score. The model's performance was validated by bootstrapping techniques. Results. A total of 316 patients were included. The median overall survival was 10 months. Multivariate Cox analysis yielded 5 prognostic variables of which the coefficients were included in the risk score. Age
Original languageEnglish
Pages (from-to)160-166
JournalNeuro-oncology
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • brainstem neoplasms
  • glioma
  • magnetic resonance imaging
  • pons
  • prognosis

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