Survival of breast cancer patients in rural Ethiopia

Pia Eber-Schulz, Wakuma Tariku, Christian Reibold, Adamu Addissie, Claudia Wickenhauser, Christine Fathke, Steffen Hauptmann, Ahmedin Jemal, Christoph Thomssen, Eva Johanna Kantelhardt*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)

Abstract

To describe the histopathological characteristics and survival of female breast cancer (BC) patients in a rural setting with limited access to adjuvant treatment. A prospective study of 107 histologically confirmed BC patients treated with surgery from 2010 to 2016 from rural parts of western Ethiopia. Referral pathology was performed, and active follow-up was conducted. Adjusted cox regression analysis (hazard ratio [HR]) was performed. The median age at diagnosis was 45 (16-83) years; 57% of the patients presented with cT3/4 tumors, 71% with clinically positive lymph nodes, 21% with HER2-overexpression (Dako3+) and 68% with grade 3 tumors. Estrogen and/or progesterone receptor expressions were present in 66% and triple-negative disease in 25%. The estimated 1- and 2-year overall survival probability rates were 78 and 53%, respectively. The 2-year survival for patients with clinically positive lymph nodes was 44% compared to 73% for patients with lymph node-negative disease (HR 2.44; 95% confidence interval [95% CI] 1.19-5.02). The corresponding 2-year survival for patients with cT4 tumors was 25% versus 68% for patients with cT1-2 tumors (cT1-3 vs. cT4 HR 3.86; 95% CI 1.82-13.63). The 2-year survival for patients with hormone receptor-negative disease was 40% compared to 59% for patients with hormone receptor-positive disease (HR 1.92; 95% CI 1.06-3.47). The majority of breast cancer patients treated with surgery in rural parts of western Ethiopia are diagnosed at advanced stage and have hormone receptor-positive disease. Nearly half of the patients die within 2 years. These findings underscore the need for provision of adjuvant hormonal therapy and for the establishment of pathology service including hormone receptor testing.
Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalBreast Cancer Research and Treatment
Volume170
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Breast cancer
  • Africa
  • Survival
  • Prognostic factors
  • Ethiopia
  • SUB-SAHARAN AFRICA
  • INCOME COUNTRIES
  • FOLLOW-UP
  • RECEPTOR
  • PREVALENCE
  • EXPRESSION
  • DIAGNOSIS
  • STAGE

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