Supramolecular Biomaterials in the Netherlands

Matthew B Baker*, Tonny Bosman, Martijn A J Cox, Patricia Dankers, Aylvin Dias, Pascal Jonkheijm, Roxanne Kieltyka

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

Synthetically designed biomaterials strive to recapitulate and mimic the complex environment of natural systems. Using natural materials as a guide, the ability to create high performance biomaterials that control cell fate, and support the next generation of cell and tissue-based therapeutics, is starting to emerge. Supramolecular chemistry takes inspiration from the wealth of non-covalent interactions found in natural materials that are inherently complex, and using the skills of synthetic and polymer chemistry, recreates simple systems to imitate their features. Within the past decade, supramolecular biomaterials have shown utility in tissue engineering and the progress predicts a bright future. On this 30th anniversary of the Netherlands Biomaterials and Tissue Engineering society, we will briefly recount the state of supramolecular biomaterials in the Dutch academic and industrial research and development context. This review will provide the background, recent advances, industrial successes and challenges, as well as future directions of the field, as we see it. Throughout this work, we notice the intricate interplay between simplicity and complexity in creating more advanced solutions. We hope that the interplay and juxtaposition between these two forces can propel the field forward.

Original languageEnglish
Pages (from-to)511-524
Number of pages14
JournalTissue Engineering. Part A
Volume28
Issue number11-12
Early online date22 Mar 2022
DOIs
Publication statusPublished - 1 Jun 2022

Keywords

  • ASSEMBLIES
  • BIOACTIVE SCAFFOLDS
  • DELIVERY
  • EXTRACELLULAR-MATRIX
  • HEART-VALVE
  • MOLECULES
  • POLYMERIZATION
  • POLYMERS
  • STEM-CELL
  • VASCULAR GRAFT
  • biomaterials
  • supramolecular biomaterials
  • tissue engineering

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