TY - JOUR
T1 - Supplementation with Qter (R) and Creatine improves functional performance in COPD patients on long term oxygen therapy
AU - De Benedetto, Fernando
AU - Pastorelli, Roberta
AU - Ferrario, Manuela
AU - de Blasio, Francesca
AU - Marinari, Stefano
AU - Brunelli, Laura
AU - Wouters, Ernie F. M.
AU - Polverino, Francesca
AU - Celli, Bartolome R.
AU - Interdisciplinary Assoc Res Lung D
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O-2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer (R)) - a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function - and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O-2 therapy. Methods: One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured. Findings: Ninety patients, who randomly received supplementation with QTer (R) and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 +/- 69 versus 15 +/- 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups. Interpretation: These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer (R) and Creatine supplementation in patients with COPD.
AB - Background: Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O-2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer (R)) - a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function - and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O-2 therapy. Methods: One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured. Findings: Ninety patients, who randomly received supplementation with QTer (R) and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 +/- 69 versus 15 +/- 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups. Interpretation: These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer (R) and Creatine supplementation in patients with COPD.
KW - COPD
KW - Bioimpedance
KW - Coenzime Q10
KW - Creatine
KW - Metabolomics
KW - 6-Minute walk test
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - BIOELECTRICAL-IMPEDANCE ANALYSIS
KW - BODY CELL MASS
KW - SKELETAL-MUSCLE MASS
KW - QUALITY-OF-LIFE
KW - NUTRITIONAL-STATUS
KW - PHASE-ANGLE
KW - COENZYME Q(10)
KW - 6-MINUTE WALK
KW - HOSPITALIZED-PATIENTS
U2 - 10.1016/j.rmed.2018.08.002
DO - 10.1016/j.rmed.2018.08.002
M3 - Article
C2 - 30170808
SN - 0954-6111
VL - 142
SP - 86
EP - 93
JO - Respiratory Medicine
JF - Respiratory Medicine
ER -