TY - JOUR
T1 - Supplementation of prebiotics to a whey-based beverage reduces the risk of hypercholesterolaemia in rats
AU - Yasmin, Adeela
AU - Butt, Masood Sadiq
AU - van Baak, Marleen
AU - Shahid, Muhammad Zia
PY - 2015/9
Y1 - 2015/9
N2 - Fructooligosaccharide-supplemented whey drinks may have potential as an interventional strategy for lowering cholesterol and triglyceride levels in dyslipidaemic conditions. A bioefficacy study was conducted in normal, hypercholesterolaemic and hyperglycaemic Sprague Dawley rats, running two consecutive trials for validity of results. Control drink (T-0), whey drink (T-1) and whey drink supplemented with 1.5% fructooligosaccharides (T-4), were given to each group. The functional drink caused a significant reduction in serum total cholesterol, low density lipoprotein (LDL) and triglycerides, and an increase in high density lipoprotein. The greatest decline in total cholesterol was induced by T-4 (10.9% and 12.0% in hypercholesterolaemic rats and 7.0% and 7.7% in hyperglycaemic rats, for trials 1 and 2, respectively). The decrease in total cholesterol by T-4 was mainly due to a pronounced decrease in LDL cholesterol (14.7% and 16.1% in hypercholesterolaemic rats and 7.4% and 8.1% in hyperglycaemic rats for trials 1 and 2, respectively).
AB - Fructooligosaccharide-supplemented whey drinks may have potential as an interventional strategy for lowering cholesterol and triglyceride levels in dyslipidaemic conditions. A bioefficacy study was conducted in normal, hypercholesterolaemic and hyperglycaemic Sprague Dawley rats, running two consecutive trials for validity of results. Control drink (T-0), whey drink (T-1) and whey drink supplemented with 1.5% fructooligosaccharides (T-4), were given to each group. The functional drink caused a significant reduction in serum total cholesterol, low density lipoprotein (LDL) and triglycerides, and an increase in high density lipoprotein. The greatest decline in total cholesterol was induced by T-4 (10.9% and 12.0% in hypercholesterolaemic rats and 7.0% and 7.7% in hyperglycaemic rats, for trials 1 and 2, respectively). The decrease in total cholesterol by T-4 was mainly due to a pronounced decrease in LDL cholesterol (14.7% and 16.1% in hypercholesterolaemic rats and 7.4% and 8.1% in hyperglycaemic rats for trials 1 and 2, respectively).
U2 - 10.1016/j.idairyj.2015.01.012
DO - 10.1016/j.idairyj.2015.01.012
M3 - Article
SN - 0958-6946
VL - 48
SP - 80
EP - 84
JO - International Dairy Journal
JF - International Dairy Journal
ER -