Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial

Hanne Lamberink; Sammy Huygens; Robina Aerts; Katrien Lagrou; Elena van Leeuwen-Segarceanu; Tom Lodewyck; Laurens Nieuwenhuizen; Maarten F Corsten; Ine Moors; Sophie Servais; Julien De Greef; Maya Hites; Astrid Demandt; Alexander Schauwvlieghe; Johan Maertens; Bart Rijnders

doi:10.1093/cid/ciae501

Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial

Hanne Lamberink, Sammy Huygens, Robina Aerts, Katrien Lagrou, Elena van Leeuwen-Segarceanu, Tom Lodewyck, Laurens Nieuwenhuizen, Maarten F Corsten, Ine Moors, Sophie Servais, Julien De Greef, Maya Hites, Astrid Demandt, Alexander Schauwvlieghe, Johan Maertens, Bart Rijnders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.

Original language	English
Journal	Clinical Infectious Diseases
DOIs	https://doi.org/10.1093/cid/ciae501
Publication status	E-pub ahead of print - 8 Oct 2024

Keywords

azole
combination therapy
echinocandin
invasive aspergillosis

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10.1093/cid/ciae501Licence: CC BY-NC-ND

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Lamberink, H., Huygens, S., Aerts, R., Lagrou, K., van Leeuwen-Segarceanu, E., Lodewyck, T., Nieuwenhuizen, L., Corsten, M. F., Moors, I., Servais, S., De Greef, J., Hites, M., Demandt, A., Schauwvlieghe, A., Maertens, J., & Rijnders, B. (2024). Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial. Clinical Infectious Diseases. Advance online publication. https://doi.org/10.1093/cid/ciae501

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title = "Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial",

abstract = "The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.",

keywords = "azole, combination therapy, echinocandin, invasive aspergillosis",

author = "Hanne Lamberink and Sammy Huygens and Robina Aerts and Katrien Lagrou and {van Leeuwen-Segarceanu}, Elena and Tom Lodewyck and Laurens Nieuwenhuizen and Corsten, {Maarten F} and Ine Moors and Sophie Servais and {De Greef}, Julien and Maya Hites and Astrid Demandt and Alexander Schauwvlieghe and Johan Maertens and Bart Rijnders",

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month = oct,

day = "8",

doi = "10.1093/cid/ciae501",

language = "English",

journal = "Clinical Infectious Diseases",

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Lamberink, H, Huygens, S, Aerts, R, Lagrou, K, van Leeuwen-Segarceanu, E, Lodewyck, T, Nieuwenhuizen, L, Corsten, MF, Moors, I, Servais, S, De Greef, J, Hites, M, Demandt, A, Schauwvlieghe, A, Maertens, J & Rijnders, B 2024, 'Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial', Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciae501

TY - JOUR

T1 - Superiority trials in invasive aspergillosis

T2 - a harsh reality check with the IA-DUET (HOVON502) trial

AU - Lamberink, Hanne

AU - Huygens, Sammy

AU - Aerts, Robina

AU - Lagrou, Katrien

AU - van Leeuwen-Segarceanu, Elena

AU - Lodewyck, Tom

AU - Nieuwenhuizen, Laurens

AU - Corsten, Maarten F

AU - Moors, Ine

AU - Servais, Sophie

AU - De Greef, Julien

AU - Hites, Maya

AU - Demandt, Astrid

AU - Schauwvlieghe, Alexander

AU - Maertens, Johan

AU - Rijnders, Bart

PY - 2024/10/8

Y1 - 2024/10/8

N2 - The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.

AB - The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.

KW - azole

KW - combination therapy

KW - echinocandin

KW - invasive aspergillosis

U2 - 10.1093/cid/ciae501

DO - 10.1093/cid/ciae501

M3 - Article

SN - 1058-4838

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

ER -

Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial

Abstract

Keywords

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