Successful Systemic and Topical Treatment of Mycobacterium abscessus Otomastoiditis

Floor van Wijk, Jerome Waterval, Koen van Aerde, Stefanie S. Henriet, F. J. Anton Meijer, Lennaert C. Borra, Rob E. Aarnoutse, Jakko van Ingen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intravenous imipenem and tigecycline, and oral clofazimine and azithromycin and adjunctive surgery. This structured approach led to cure, with 1 year of follow-up after treatment. Adverse events were frequent, mostly caused by tigecycline.

Original languageEnglish
Article numbere01203-19
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Issue number1
Publication statusPublished - Jan 2020


  • Mycobacterium abscessus
  • mastoiditis
  • otitis
  • tigecycline
  • clofazimine
  • Mycobacterium
  • experimental therapeutics
  • otitis media
  • pediatric drug therapy

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