Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation

Kai Markus Schneider, Theresa H Wirtz, Daniela Kroy, Stefanie Albers, Ulf Peter Neumann, Till Strowig, Gernot Sellge, Christian Trautwein

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalCase Reports in Gastroenterology
Volume12
Issue number1
DOIs
Publication statusPublished - 3 Apr 2018

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