TY - JOUR
T1 - Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation
AU - Schneider, Kai Markus
AU - Wirtz, Theresa H
AU - Kroy, Daniela
AU - Albers, Stefanie
AU - Neumann, Ulf Peter
AU - Strowig, Till
AU - Sellge, Gernot
AU - Trautwein, Christian
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.
AB - Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.
U2 - 10.1159/000481937
DO - 10.1159/000481937
M3 - (Systematic) Review article
C2 - 29606940
SN - 1662-0631
VL - 12
SP - 76
EP - 84
JO - Case Reports in Gastroenterology
JF - Case Reports in Gastroenterology
IS - 1
ER -