Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI

Harm J. van de Haar, Jacobus F. A. Jansen, Cecile R. L. P. N. Jeukens, Saartje Burgmans, Mark A. van Buchem, Majon Muller, Paul A. M. Hofman, Frans R. J. Verhey, Matthias J. P. van Osch, Walter H. Backes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)4112-4125
Number of pages14
JournalMedical Physics
Volume44
Issue number8
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Alzheimer's disease
  • blood-brain barrier
  • brain MRI
  • dynamic contrast-enhanced MRI
  • leakage
  • pharmacokinetic modeling
  • DCE-MRI
  • TEMPORAL RESOLUTION
  • ALZHEIMERS-DISEASE
  • IN-VIVO
  • 3 TESLA
  • PERMEABILITY
  • PARAMETERS
  • MODEL
  • QUANTIFICATION
  • ACQUISITION

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