Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia

Leonoor van Eerden; Christianne J. M. de Groot; Gerda G. Zeeman; Godelieve C. M. Page-Christiaens; Eva Pajkrt; Johannes J. Duvekot; Frank P. Vandenbussche; Swan G. Oei; Hubertina C. J. Scheepers; Jim van Eyck; Johanna M. Middeldorp; Antoinette C. Bolte

doi:10.1111/ajo.12691

Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia

Leonoor van Eerden^*, Christianne J. M. de Groot, Gerda G. Zeeman, Godelieve C. M. Page-Christiaens, Eva Pajkrt, Johannes J. Duvekot, Frank P. Vandenbussche, Swan G. Oei, Hubertina C. J. Scheepers, Jim van Eyck, Johanna M. Middeldorp, Antoinette C. Bolte

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Web of Science)

Abstract

BackgroundIn this study we determined the outcome of subsequent pregnancies after termination of pregnancy for preeclampsia, with the purpose of presenting data useful for counselling these women on future pregnancies.

Study designThe cohort consisted of 131 women with a history of termination of pregnancy for preeclampsia.

ResultsData of 79 pregnancies were available for analysis, including 13 women with chronic hypertension and 16 women with thrombophilia. There were seven miscarriages (8.8%) and 72 ongoing pregnancies. Low-dose aspirin was prescribed for 64 women (89%). The mean gestational age at delivery was 356/74weeks with a mean birth weight of 2571 +/- 938g. Overall recurrence rate for preeclampsia was 29% at a mean gestational age of 32weeks. Thirty-eight women had an uncomplicated pregnancy (53%). The women with chronic hypertension had the highest recurrence rate of 38%. Neonatal mortality was4%.

ConclusionThe course of subsequent pregnancies after mid-trimester termination for preeclampsia is uncomplicated in 53% with a recurrence rate for preeclampsia of 29%. The mean gestational age at delivery was 11weeks later and birth weight 2000g higher than in the index pregnancy.

Original language	English
Pages (from-to)	204-209
Number of pages	6
Journal	Australian & New Zealand Journal of Obstetrics & Gynaecology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1111/ajo.12691
Publication status	Published - Apr 2018

Keywords

early onset preeclampsia
pregnancy outcome
recurrence risk
PREVENTION
GESTATION
DELIVERY
ASPIRIN
HISTORY
SCREEN
ONSET
WOMEN
RISK
TERM

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10.1111/ajo.12691

Cite this

van Eerden, L., de Groot, C. J. M., Zeeman, G. G., Page-Christiaens, G. C. M., Pajkrt, E., Duvekot, J. J., Vandenbussche, F. P., Oei, S. G., Scheepers, H. C. J., van Eyck, J., Middeldorp, J. M., & Bolte, A. C. (2018). Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia. Australian & New Zealand Journal of Obstetrics & Gynaecology, 58(2), 204-209. https://doi.org/10.1111/ajo.12691

@article{623eb840b86145adb1aee95e1adeb675,

title = "Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia",

abstract = "BackgroundIn this study we determined the outcome of subsequent pregnancies after termination of pregnancy for preeclampsia, with the purpose of presenting data useful for counselling these women on future pregnancies.Study designThe cohort consisted of 131 women with a history of termination of pregnancy for preeclampsia.ResultsData of 79 pregnancies were available for analysis, including 13 women with chronic hypertension and 16 women with thrombophilia. There were seven miscarriages (8.8%) and 72 ongoing pregnancies. Low-dose aspirin was prescribed for 64 women (89%). The mean gestational age at delivery was 356/74weeks with a mean birth weight of 2571 +/- 938g. Overall recurrence rate for preeclampsia was 29% at a mean gestational age of 32weeks. Thirty-eight women had an uncomplicated pregnancy (53%). The women with chronic hypertension had the highest recurrence rate of 38%. Neonatal mortality was4%.ConclusionThe course of subsequent pregnancies after mid-trimester termination for preeclampsia is uncomplicated in 53% with a recurrence rate for preeclampsia of 29%. The mean gestational age at delivery was 11weeks later and birth weight 2000g higher than in the index pregnancy.",

keywords = "early onset preeclampsia, pregnancy outcome, recurrence risk, PREVENTION, GESTATION, DELIVERY, ASPIRIN, HISTORY, SCREEN, ONSET, WOMEN, RISK, TERM",

author = "{van Eerden}, Leonoor and {de Groot}, {Christianne J. M.} and Zeeman, {Gerda G.} and Page-Christiaens, {Godelieve C. M.} and Eva Pajkrt and Duvekot, {Johannes J.} and Vandenbussche, {Frank P.} and Oei, {Swan G.} and Scheepers, {Hubertina C. J.} and {van Eyck}, Jim and Middeldorp, {Johanna M.} and Bolte, {Antoinette C.}",

year = "2018",

month = apr,

doi = "10.1111/ajo.12691",

language = "English",

volume = "58",

pages = "204--209",

journal = "Australian & New Zealand Journal of Obstetrics & Gynaecology",

issn = "0004-8666",

publisher = "Wiley",

number = "2",

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van Eerden, L, de Groot, CJM, Zeeman, GG, Page-Christiaens, GCM, Pajkrt, E, Duvekot, JJ, Vandenbussche, FP, Oei, SG, Scheepers, HCJ, van Eyck, J, Middeldorp, JM & Bolte, AC 2018, 'Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia', Australian & New Zealand Journal of Obstetrics & Gynaecology, vol. 58, no. 2, pp. 204-209. https://doi.org/10.1111/ajo.12691

TY - JOUR

T1 - Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia

AU - van Eerden, Leonoor

AU - de Groot, Christianne J. M.

AU - Zeeman, Gerda G.

AU - Page-Christiaens, Godelieve C. M.

AU - Pajkrt, Eva

AU - Duvekot, Johannes J.

AU - Vandenbussche, Frank P.

AU - Oei, Swan G.

AU - Scheepers, Hubertina C. J.

AU - van Eyck, Jim

AU - Middeldorp, Johanna M.

AU - Bolte, Antoinette C.

PY - 2018/4

Y1 - 2018/4

N2 - BackgroundIn this study we determined the outcome of subsequent pregnancies after termination of pregnancy for preeclampsia, with the purpose of presenting data useful for counselling these women on future pregnancies.Study designThe cohort consisted of 131 women with a history of termination of pregnancy for preeclampsia.ResultsData of 79 pregnancies were available for analysis, including 13 women with chronic hypertension and 16 women with thrombophilia. There were seven miscarriages (8.8%) and 72 ongoing pregnancies. Low-dose aspirin was prescribed for 64 women (89%). The mean gestational age at delivery was 356/74weeks with a mean birth weight of 2571 +/- 938g. Overall recurrence rate for preeclampsia was 29% at a mean gestational age of 32weeks. Thirty-eight women had an uncomplicated pregnancy (53%). The women with chronic hypertension had the highest recurrence rate of 38%. Neonatal mortality was4%.ConclusionThe course of subsequent pregnancies after mid-trimester termination for preeclampsia is uncomplicated in 53% with a recurrence rate for preeclampsia of 29%. The mean gestational age at delivery was 11weeks later and birth weight 2000g higher than in the index pregnancy.

AB - BackgroundIn this study we determined the outcome of subsequent pregnancies after termination of pregnancy for preeclampsia, with the purpose of presenting data useful for counselling these women on future pregnancies.Study designThe cohort consisted of 131 women with a history of termination of pregnancy for preeclampsia.ResultsData of 79 pregnancies were available for analysis, including 13 women with chronic hypertension and 16 women with thrombophilia. There were seven miscarriages (8.8%) and 72 ongoing pregnancies. Low-dose aspirin was prescribed for 64 women (89%). The mean gestational age at delivery was 356/74weeks with a mean birth weight of 2571 +/- 938g. Overall recurrence rate for preeclampsia was 29% at a mean gestational age of 32weeks. Thirty-eight women had an uncomplicated pregnancy (53%). The women with chronic hypertension had the highest recurrence rate of 38%. Neonatal mortality was4%.ConclusionThe course of subsequent pregnancies after mid-trimester termination for preeclampsia is uncomplicated in 53% with a recurrence rate for preeclampsia of 29%. The mean gestational age at delivery was 11weeks later and birth weight 2000g higher than in the index pregnancy.

KW - early onset preeclampsia

KW - pregnancy outcome

KW - recurrence risk

KW - PREVENTION

KW - GESTATION

KW - DELIVERY

KW - ASPIRIN

KW - HISTORY

KW - SCREEN

KW - ONSET

KW - WOMEN

KW - RISK

KW - TERM

U2 - 10.1111/ajo.12691

DO - 10.1111/ajo.12691

M3 - Article

C2 - 28850666

SN - 0004-8666

VL - 58

SP - 204

EP - 209

JO - Australian & New Zealand Journal of Obstetrics & Gynaecology

JF - Australian & New Zealand Journal of Obstetrics & Gynaecology

IS - 2

ER -