Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Rosalinde E. R. Slot; Sietske A. M. Sikkes; Johannes Berkhof; Henry Brodaty; Rachel Buckley; Enrica Cavedo; Efthimios Dardiotis; Francoise Guillo-Benarous; Harald Hampel; Nicole A. Kochan; Simone Lista; Tobias Luck; Paul Maruff; Jose Luis Molinuevo; Johannes Kornhuber; Barry Reisberg; Steffi G. Riedel-Heller; Shannon L. Risacher; Susanne Roehr; Perminder S. Sachdev; Nikolaos Scarmeas; Philip Scheltens; Melanie B. Shulman; Andrew J. Saykin; Sander C. J. Verfaillie; Pieter Jelle Visser; Stephanie J. B. Vos; Michael Wagner; Steffen Wolfsgruber; Frank Jessen; Wiesje M. van der Flier; Alzheimer's Disease Neuroimaging Initiative; DESCRIPA working group; Insight-PreAD Study Grp; SCD‐I working group

doi:10.1016/j.jalz.2018.10.003

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Rosalinde E. R. Slot, Sietske A. M. Sikkes, Johannes Berkhof, Henry Brodaty, Rachel Buckley, Enrica Cavedo, Efthimios Dardiotis, Francoise Guillo-Benarous, Harald Hampel, Nicole A. Kochan, Simone Lista, Tobias Luck, Paul Maruff, Jose Luis Molinuevo, Johannes Kornhuber, Barry Reisberg, Steffi G. Riedel-Heller, Shannon L. Risacher, Susanne Roehr, Perminder S. SachdevNikolaos Scarmeas, Philip Scheltens, Melanie B. Shulman, Andrew J. Saykin, Sander C. J. Verfaillie, Pieter Jelle Visser, Stephanie J. B. Vos, Michael Wagner, Steffen Wolfsgruber, Frank Jessen, Wiesje M. van der Flier^*, Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group , Insight-PreAD Study Grp, SCD‐I working group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

139 Citations (Web of Science)

Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.

Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.

Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia.

Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.

Original language	English
Pages (from-to)	465-476
Number of pages	12
Journal	Alzheimer's & Dementia
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2018.10.003
Publication status	Published - Mar 2019

Keywords

Subjective cognitive decline
Dementia incidence
Preclinical Alzheimer's disease
Alzheimer's disease
Vascular dementia
Frontotemporal dementia
Dementia Lewy bodies
BASE-LINE CHARACTERISTICS
MEMORY COMPLAINTS
ASSOCIATION WORKGROUPS
DIAGNOSTIC GUIDELINES
NATIONAL INSTITUTE
RECRUITMENT METHODS
APOLIPOPROTEIN-E
MAJOR SUBTYPES
OLDER-ADULTS
IMPAIRMENT

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10.1016/j.jalz.2018.10.003

Cite this

Slot, R. E. R., Sikkes, S. A. M., Berkhof, J., Brodaty, H., Buckley, R., Cavedo, E., Dardiotis, E., Guillo-Benarous, F., Hampel, H., Kochan, N. A., Lista, S., Luck, T., Maruff, P., Molinuevo, J. L., Kornhuber, J., Reisberg, B., Riedel-Heller, S. G., Risacher, S. L., Roehr, S., ... SCD‐I working group (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimer's & Dementia, 15(3), 465-476. https://doi.org/10.1016/j.jalz.2018.10.003

@article{eeff25a92e6b4f00bf96dec8864fb523,

title = "Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia",

abstract = "Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia.Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.",

keywords = "Subjective cognitive decline, Dementia incidence, Preclinical Alzheimer's disease, Alzheimer's disease, Vascular dementia, Frontotemporal dementia, Dementia Lewy bodies, BASE-LINE CHARACTERISTICS, MEMORY COMPLAINTS, ASSOCIATION WORKGROUPS, DIAGNOSTIC GUIDELINES, NATIONAL INSTITUTE, RECRUITMENT METHODS, APOLIPOPROTEIN-E, MAJOR SUBTYPES, OLDER-ADULTS, IMPAIRMENT",

author = "Slot, {Rosalinde E. R.} and Sikkes, {Sietske A. M.} and Johannes Berkhof and Henry Brodaty and Rachel Buckley and Enrica Cavedo and Efthimios Dardiotis and Francoise Guillo-Benarous and Harald Hampel and Kochan, {Nicole A.} and Simone Lista and Tobias Luck and Paul Maruff and Molinuevo, {Jose Luis} and Johannes Kornhuber and Barry Reisberg and Riedel-Heller, {Steffi G.} and Risacher, {Shannon L.} and Susanne Roehr and Sachdev, {Perminder S.} and Nikolaos Scarmeas and Philip Scheltens and Shulman, {Melanie B.} and Saykin, {Andrew J.} and Verfaillie, {Sander C. J.} and Visser, {Pieter Jelle} and Vos, {Stephanie J. B.} and Michael Wagner and Steffen Wolfsgruber and Frank Jessen and {van der Flier}, {Wiesje M.} and {Alzheimer's Disease Neuroimaging Initiative} and {DESCRIPA working group} and {Insight-PreAD Study Grp} and {SCD‐I working group}",

year = "2019",

month = mar,

doi = "10.1016/j.jalz.2018.10.003",

language = "English",

volume = "15",

pages = "465--476",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier Science",

number = "3",

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Slot, RER, Sikkes, SAM, Berkhof, J, Brodaty, H, Buckley, R, Cavedo, E, Dardiotis, E, Guillo-Benarous, F, Hampel, H, Kochan, NA, Lista, S, Luck, T, Maruff, P, Molinuevo, JL, Kornhuber, J, Reisberg, B, Riedel-Heller, SG, Risacher, SL, Roehr, S, Sachdev, PS, Scarmeas, N, Scheltens, P, Shulman, MB, Saykin, AJ, Verfaillie, SCJ, Visser, PJ , Vos, SJB, Wagner, M, Wolfsgruber, S, Jessen, F, van der Flier, WM, Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group , Insight-PreAD Study Grp & SCD‐I working group 2019, 'Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia', Alzheimer's & Dementia, vol. 15, no. 3, pp. 465-476. https://doi.org/10.1016/j.jalz.2018.10.003

TY - JOUR

T1 - Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

AU - Slot, Rosalinde E. R.

AU - Sikkes, Sietske A. M.

AU - Berkhof, Johannes

AU - Brodaty, Henry

AU - Buckley, Rachel

AU - Cavedo, Enrica

AU - Dardiotis, Efthimios

AU - Guillo-Benarous, Francoise

AU - Hampel, Harald

AU - Kochan, Nicole A.

AU - Lista, Simone

AU - Luck, Tobias

AU - Maruff, Paul

AU - Molinuevo, Jose Luis

AU - Kornhuber, Johannes

AU - Reisberg, Barry

AU - Riedel-Heller, Steffi G.

AU - Risacher, Shannon L.

AU - Roehr, Susanne

AU - Sachdev, Perminder S.

AU - Scarmeas, Nikolaos

AU - Scheltens, Philip

AU - Shulman, Melanie B.

AU - Saykin, Andrew J.

AU - Verfaillie, Sander C. J.

AU - Visser, Pieter Jelle

AU - Vos, Stephanie J. B.

AU - Wagner, Michael

AU - Wolfsgruber, Steffen

AU - Jessen, Frank

AU - van der Flier, Wiesje M.

AU - Alzheimer's Disease Neuroimaging Initiative

AU - DESCRIPA working group

AU - Insight-PreAD Study Grp

AU - SCD‐I working group

PY - 2019/3

Y1 - 2019/3

N2 - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia.Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.

AB - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia.Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.

KW - Subjective cognitive decline

KW - Dementia incidence

KW - Preclinical Alzheimer's disease

KW - Alzheimer's disease

KW - Vascular dementia

KW - Frontotemporal dementia

KW - Dementia Lewy bodies

KW - BASE-LINE CHARACTERISTICS

KW - MEMORY COMPLAINTS

KW - ASSOCIATION WORKGROUPS

KW - DIAGNOSTIC GUIDELINES

KW - NATIONAL INSTITUTE

KW - RECRUITMENT METHODS

KW - APOLIPOPROTEIN-E

KW - MAJOR SUBTYPES

KW - OLDER-ADULTS

KW - IMPAIRMENT

U2 - 10.1016/j.jalz.2018.10.003

DO - 10.1016/j.jalz.2018.10.003

M3 - Article

VL - 15

SP - 465

EP - 476

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 3

ER -