Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Rosalinde E. R. Slot, Sietske A. M. Sikkes, Johannes Berkhof, Henry Brodaty, Rachel Buckley, Enrica Cavedo, Efthimios Dardiotis, Francoise Guillo-Benarous, Harald Hampel, Nicole A. Kochan, Simone Lista, Tobias Luck, Paul Maruff, Jose Luis Molinuevo, Johannes Kornhuber, Barry Reisberg, Steffi G. Riedel-Heller, Shannon L. Risacher, Susanne Roehr, Perminder S. SachdevNikolaos Scarmeas, Philip Scheltens, Melanie B. Shulman, Andrew J. Saykin, Sander C. J. Verfaillie, Pieter Jelle Visser, Stephanie J. B. Vos, Michael Wagner, Steffen Wolfsgruber, Frank Jessen, Wiesje M. van der Flier*, Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group , Insight-PreAD Study Grp, SCD‐I working group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

139 Citations (Web of Science)

Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.

Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.

Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia.

Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)465-476
Number of pages12
JournalAlzheimer's & Dementia
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Subjective cognitive decline
  • Dementia incidence
  • Preclinical Alzheimer's disease
  • Alzheimer's disease
  • Vascular dementia
  • Frontotemporal dementia
  • Dementia Lewy bodies
  • BASE-LINE CHARACTERISTICS
  • MEMORY COMPLAINTS
  • ASSOCIATION WORKGROUPS
  • DIAGNOSTIC GUIDELINES
  • NATIONAL INSTITUTE
  • RECRUITMENT METHODS
  • APOLIPOPROTEIN-E
  • MAJOR SUBTYPES
  • OLDER-ADULTS
  • IMPAIRMENT

Cite this