Subclinical psychotic experiences and cognitive functioning as a bivariate phenotype for genetic studies in the general population

C.J.P. Simons, N.E. Jacobs, J. Jolles, J.J. van Os, L. Krabbendam*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: Cognitive deficits may be vulnerability markers for the development of schizophrenia. This study examined whether cognitive deficits are related to specific dimensions of subclinical psychotic experiences and whether associations between these variables are caused by additive genetic, common environmental and/or individual-specific environmental factors. Method: A general population sample of 298 female twin pairs completed the Community Assessment of Psychic Experiences and a neuropsychological test battery. Associations between subclinical positive and negative psychotic dimensions and neuropsychological factors (episodic memory and information processing speed) were examined. Univariate correlation and structural equation analyses were performed to explore the role of genetic and environmental factors in the phenotypes separately. Bivariate correlation and structural equation analyses were applied to examine the causes of association. Results: There were significant correlations between information processing speed and both the positive (r=.11; p
Original languageEnglish
Pages (from-to)24-31
JournalSchizophrenia Research
Volume92 (1-3)
Publication statusPublished - 1 Jan 2007

Cite this