Subclinical Hypothyroidism after Vascular Complicated Pregnancy

Moniek van der Zanden*, Rianne J. Hop-de Groot, Fred C. G. J. Sweep, H. Alec Ross, Martin den Heijer, Marc E. A. Spaanderman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Women with a history of vascular complicated pregnancy are at risk for developing remote cardiovascular disease. It is associated with underlying cardiovascular risk factors both jeopardizing trophoblast and vascular function. Subclinical hypothyroidism may relate to both conditions.In 372 women with a history of vascular complicated pregnancy, we assessed thyroid function.Subclinical hypothyroidism was diagnosed in 73/372 women (19.6%). It occurred more often when pregnancy ended before 32 weeks of gestation (p = 0.008).In this cohort, subclinical hypothyroidism is more common after very preterm delivery. It may contribute to the elevated risk of remote cardiovascular disease.
Original languageEnglish
Pages (from-to)1-10
JournalHypertension in Pregnancy
Issue number1
Publication statusPublished - 2013


  • Subclinical hypothyroidism
  • Vascular complicated pregnancy
  • Preterm delivery
  • Preeclampsia
  • Dyslipidemia

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