Studying the Effect of Adhesive Layer Composition on MIP-Based Thermal Biosensing

Renato Rogosic; Joseph W. Lowdon; Benjamin Heidt; Hanne Dilien; Kasper Eersels; Bart Van Grinsven; Thomas J. Cleij

doi:10.1002/pssa.201800941

Studying the Effect of Adhesive Layer Composition on MIP-Based Thermal Biosensing

Renato Rogosic, Joseph W. Lowdon, Benjamin Heidt, Hanne Dilien, Kasper Eersels^*, Bart Van Grinsven, Thomas J. Cleij

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Molecularly imprinted polymer (MIP)-based thermal sensing has proven to be a very interesting tool for diagnostic purposes. However, many fundamental phenomena are not yet fully understood. In the following study, MIPs are imprinted with the new psychoactive substance methoxphenidine (2-MXP). Thermal detection of this compound in water is demonstrated for the very first time and the effect of varying the adhesive layer composition on the performance of the sensor is analyzed. Three different polymers are used to create a uniform adhesive layer. The surface coverage of MIPs on each of the layers as well as the heat-transfer properties are studied. The results of the study indicate that the chips coated with poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) display a higher surface coverage and a lower thermal resistance value. This results in an improved effect size and therefore improves dynamic range of the sensor.

Original language	English
Article number	1800941
Number of pages	6
Journal	Physica Status Solidi A-applications and Materials Science
Volume	216
Issue number	12
DOIs	https://doi.org/10.1002/pssa.201800941
Publication status	Published - Jun 2019

Keywords

adhesive layer composition analysis
designer drug detection
heat-transfer method
molecularly imprinted polymers
MOLECULARLY IMPRINTED POLYMERS
LABEL-FREE DETECTION
TRANSPORT

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10.1002/pssa.201800941

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title = "Studying the Effect of Adhesive Layer Composition on MIP-Based Thermal Biosensing",

abstract = "Molecularly imprinted polymer (MIP)-based thermal sensing has proven to be a very interesting tool for diagnostic purposes. However, many fundamental phenomena are not yet fully understood. In the following study, MIPs are imprinted with the new psychoactive substance methoxphenidine (2-MXP). Thermal detection of this compound in water is demonstrated for the very first time and the effect of varying the adhesive layer composition on the performance of the sensor is analyzed. Three different polymers are used to create a uniform adhesive layer. The surface coverage of MIPs on each of the layers as well as the heat-transfer properties are studied. The results of the study indicate that the chips coated with poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) display a higher surface coverage and a lower thermal resistance value. This results in an improved effect size and therefore improves dynamic range of the sensor.",

keywords = "adhesive layer composition analysis, designer drug detection, heat-transfer method, molecularly imprinted polymers, MOLECULARLY IMPRINTED POLYMERS, LABEL-FREE DETECTION, TRANSPORT",

author = "Renato Rogosic and Lowdon, {Joseph W.} and Benjamin Heidt and Hanne Dilien and Kasper Eersels and {Van Grinsven}, Bart and Cleij, {Thomas J.}",

note = "Funding Information: The authors are grateful for the financial support received from the Province of Limburg (LiMe) and for funding from Taskforce for Applied Research of the Dutch Research Foundation (SIA-NWO) through the RAAK-PRO project “SURFSCAN.” Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = jun,

doi = "10.1002/pssa.201800941",

language = "English",

volume = "216",

journal = "Physica Status Solidi A-applications and Materials Science",

issn = "1862-6300",

publisher = "Wiley-VCH Verlag",

number = "12",

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T1 - Studying the Effect of Adhesive Layer Composition on MIP-Based Thermal Biosensing

AU - Rogosic, Renato

AU - Lowdon, Joseph W.

AU - Heidt, Benjamin

AU - Dilien, Hanne

AU - Eersels, Kasper

AU - Van Grinsven, Bart

AU - Cleij, Thomas J.

N1 - Funding Information: The authors are grateful for the financial support received from the Province of Limburg (LiMe) and for funding from Taskforce for Applied Research of the Dutch Research Foundation (SIA-NWO) through the RAAK-PRO project “SURFSCAN.” Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/6

Y1 - 2019/6

N2 - Molecularly imprinted polymer (MIP)-based thermal sensing has proven to be a very interesting tool for diagnostic purposes. However, many fundamental phenomena are not yet fully understood. In the following study, MIPs are imprinted with the new psychoactive substance methoxphenidine (2-MXP). Thermal detection of this compound in water is demonstrated for the very first time and the effect of varying the adhesive layer composition on the performance of the sensor is analyzed. Three different polymers are used to create a uniform adhesive layer. The surface coverage of MIPs on each of the layers as well as the heat-transfer properties are studied. The results of the study indicate that the chips coated with poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) display a higher surface coverage and a lower thermal resistance value. This results in an improved effect size and therefore improves dynamic range of the sensor.

AB - Molecularly imprinted polymer (MIP)-based thermal sensing has proven to be a very interesting tool for diagnostic purposes. However, many fundamental phenomena are not yet fully understood. In the following study, MIPs are imprinted with the new psychoactive substance methoxphenidine (2-MXP). Thermal detection of this compound in water is demonstrated for the very first time and the effect of varying the adhesive layer composition on the performance of the sensor is analyzed. Three different polymers are used to create a uniform adhesive layer. The surface coverage of MIPs on each of the layers as well as the heat-transfer properties are studied. The results of the study indicate that the chips coated with poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) display a higher surface coverage and a lower thermal resistance value. This results in an improved effect size and therefore improves dynamic range of the sensor.

KW - adhesive layer composition analysis

KW - designer drug detection

KW - heat-transfer method

KW - molecularly imprinted polymers

KW - MOLECULARLY IMPRINTED POLYMERS

KW - LABEL-FREE DETECTION

KW - TRANSPORT

U2 - 10.1002/pssa.201800941

DO - 10.1002/pssa.201800941

M3 - Article

SN - 1862-6300

VL - 216

JO - Physica Status Solidi A-applications and Materials Science

JF - Physica Status Solidi A-applications and Materials Science

IS - 12

M1 - 1800941

ER -

Studying the Effect of Adhesive Layer Composition on MIP-Based Thermal Biosensing

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Keywords

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