Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial

Luca Filippi; Giacomo Cavallaro; Elettra Berti; Letizia Padrini; Gabriella Araimo; Giulia Regiroli; Valentina Bozzetti; Chiara De Angelis; Paolo Tagliabue; Barbara Tomasini; Giuseppe Buonocore; Massimo Agosti; Angela Bossi; Gaetano Chirico; Salvatore Aversa; Roberta Pasqualetti; Pina Fortunato; Silvia Osnaghi; Barbara Cavallotti; Maurizio Vanni; Giulia Borsari; Simone Donati; Giuseppe Nascimbeni; Giancarlo la Marca; Giulia Forni; Silvano Milani; Ivan Cortinovis; Paola Bagnoli; Massimo Dal Monte; Anna Maria Calvani; Alessandra Pugi; Eduardo Villamor; Gianpaolo Donzelli; Fabio Mosca

doi:10.1186/s12887-017-0923-8

Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial

Luca Filippi^*, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti, Pina Fortunato, Silvia Osnaghi, Barbara Cavallotti, Maurizio VanniGiulia Borsari, Simone Donati, Giuseppe Nascimbeni, Giancarlo la Marca, Giulia Forni, Silvano Milani, Ivan Cortinovis, Paola Bagnoli, Massimo Dal Monte, Anna Maria Calvani, Alessandra Pugi, Eduardo Villamor, Gianpaolo Donzelli, Fabio Mosca

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	165
Number of pages	10
Journal	Bmc Pediatrics
Volume	17
DOIs	https://doi.org/10.1186/s12887-017-0923-8
Publication status	Published - 14 Jul 2017

Keywords

Propranolol
Beta blocker
Proliferative retinopathy
Angiogenesis
OXYGEN-INDUCED RETINOPATHY
ENDOTHELIAL GROWTH-FACTOR
BETA-ADRENERGIC-RECEPTOR
ORAL PROPRANOLOL
RETINAL NEOVASCULARIZATION
BETA-2-ADRENERGIC RECEPTOR
INFANTILE HEMANGIOMAS
BETA-3-ADRENERGIC RECEPTORS
FUNCTIONAL INVOLVEMENT
VISUAL IMPAIRMENT

Access to Document

10.1186/s12887-017-0923-8

Cite this

Filippi, L., Cavallaro, G., Berti, E., Padrini, L., Araimo, G., Regiroli, G., Bozzetti, V., De Angelis, C., Tagliabue, P., Tomasini, B., Buonocore, G., Agosti, M., Bossi, A., Chirico, G., Aversa, S., Pasqualetti, R., Fortunato, P., Osnaghi, S., Cavallotti, B., ... Mosca, F. (2017). Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial. Bmc Pediatrics, 17, [165]. https://doi.org/10.1186/s12887-017-0923-8

Filippi, Luca ; Cavallaro, Giacomo ; Berti, Elettra ; Padrini, Letizia ; Araimo, Gabriella ; Regiroli, Giulia ; Bozzetti, Valentina ; De Angelis, Chiara ; Tagliabue, Paolo ; Tomasini, Barbara ; Buonocore, Giuseppe ; Agosti, Massimo ; Bossi, Angela ; Chirico, Gaetano ; Aversa, Salvatore ; Pasqualetti, Roberta ; Fortunato, Pina ; Osnaghi, Silvia ; Cavallotti, Barbara ; Vanni, Maurizio ; Borsari, Giulia ; Donati, Simone ; Nascimbeni, Giuseppe ; la Marca, Giancarlo ; Forni, Giulia ; Milani, Silvano ; Cortinovis, Ivan ; Bagnoli, Paola ; Dal Monte, Massimo ; Calvani, Anna Maria ; Pugi, Alessandra ; Villamor, Eduardo ; Donzelli, Gianpaolo ; Mosca, Fabio. / Study protocol : safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial. In: Bmc Pediatrics. 2017 ; Vol. 17.

@article{21bde8d875044bb4b52aff04fc09e7ab,

title = "Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial",

keywords = "Propranolol, Beta blocker, Proliferative retinopathy, Angiogenesis, OXYGEN-INDUCED RETINOPATHY, ENDOTHELIAL GROWTH-FACTOR, BETA-ADRENERGIC-RECEPTOR, ORAL PROPRANOLOL, RETINAL NEOVASCULARIZATION, BETA-2-ADRENERGIC RECEPTOR, INFANTILE HEMANGIOMAS, BETA-3-ADRENERGIC RECEPTORS, FUNCTIONAL INVOLVEMENT, VISUAL IMPAIRMENT",

author = "Luca Filippi and Giacomo Cavallaro and Elettra Berti and Letizia Padrini and Gabriella Araimo and Giulia Regiroli and Valentina Bozzetti and {De Angelis}, Chiara and Paolo Tagliabue and Barbara Tomasini and Giuseppe Buonocore and Massimo Agosti and Angela Bossi and Gaetano Chirico and Salvatore Aversa and Roberta Pasqualetti and Pina Fortunato and Silvia Osnaghi and Barbara Cavallotti and Maurizio Vanni and Giulia Borsari and Simone Donati and Giuseppe Nascimbeni and {la Marca}, Giancarlo and Giulia Forni and Silvano Milani and Ivan Cortinovis and Paola Bagnoli and {Dal Monte}, Massimo and Calvani, {Anna Maria} and Alessandra Pugi and Eduardo Villamor and Gianpaolo Donzelli and Fabio Mosca",

year = "2017",

month = jul,

day = "14",

doi = "10.1186/s12887-017-0923-8",

language = "English",

volume = "17",

journal = "Bmc Pediatrics",

issn = "1471-2431",

publisher = "BioMed Central Ltd",

}

Filippi, L, Cavallaro, G, Berti, E, Padrini, L, Araimo, G, Regiroli, G, Bozzetti, V, De Angelis, C, Tagliabue, P, Tomasini, B, Buonocore, G, Agosti, M, Bossi, A, Chirico, G, Aversa, S, Pasqualetti, R, Fortunato, P, Osnaghi, S, Cavallotti, B, Vanni, M, Borsari, G, Donati, S, Nascimbeni, G, la Marca, G, Forni, G, Milani, S, Cortinovis, I, Bagnoli, P, Dal Monte, M, Calvani, AM, Pugi, A, Villamor, E, Donzelli, G & Mosca, F 2017, 'Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial', Bmc Pediatrics, vol. 17, 165. https://doi.org/10.1186/s12887-017-0923-8

Study protocol : safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial. / Filippi, Luca; Cavallaro, Giacomo; Berti, Elettra; Padrini, Letizia; Araimo, Gabriella; Regiroli, Giulia; Bozzetti, Valentina; De Angelis, Chiara; Tagliabue, Paolo; Tomasini, Barbara; Buonocore, Giuseppe; Agosti, Massimo; Bossi, Angela; Chirico, Gaetano; Aversa, Salvatore; Pasqualetti, Roberta; Fortunato, Pina; Osnaghi, Silvia; Cavallotti, Barbara; Vanni, Maurizio; Borsari, Giulia; Donati, Simone; Nascimbeni, Giuseppe; la Marca, Giancarlo; Forni, Giulia; Milani, Silvano; Cortinovis, Ivan; Bagnoli, Paola; Dal Monte, Massimo; Calvani, Anna Maria; Pugi, Alessandra; Villamor, Eduardo; Donzelli, Gianpaolo; Mosca, Fabio.

In: Bmc Pediatrics, Vol. 17, 165, 14.07.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Study protocol

T2 - safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial

AU - Filippi, Luca

AU - Cavallaro, Giacomo

AU - Berti, Elettra

AU - Padrini, Letizia

AU - Araimo, Gabriella

AU - Regiroli, Giulia

AU - Bozzetti, Valentina

AU - De Angelis, Chiara

AU - Tagliabue, Paolo

AU - Tomasini, Barbara

AU - Buonocore, Giuseppe

AU - Agosti, Massimo

AU - Bossi, Angela

AU - Chirico, Gaetano

AU - Aversa, Salvatore

AU - Pasqualetti, Roberta

AU - Fortunato, Pina

AU - Osnaghi, Silvia

AU - Cavallotti, Barbara

AU - Vanni, Maurizio

AU - Borsari, Giulia

AU - Donati, Simone

AU - Nascimbeni, Giuseppe

AU - la Marca, Giancarlo

AU - Forni, Giulia

AU - Milani, Silvano

AU - Cortinovis, Ivan

AU - Bagnoli, Paola

AU - Dal Monte, Massimo

AU - Calvani, Anna Maria

AU - Pugi, Alessandra

AU - Villamor, Eduardo

AU - Donzelli, Gianpaolo

AU - Mosca, Fabio

PY - 2017/7/14

Y1 - 2017/7/14

KW - Propranolol

KW - Beta blocker

KW - Proliferative retinopathy

KW - Angiogenesis

KW - OXYGEN-INDUCED RETINOPATHY

KW - ENDOTHELIAL GROWTH-FACTOR

KW - BETA-ADRENERGIC-RECEPTOR

KW - ORAL PROPRANOLOL

KW - RETINAL NEOVASCULARIZATION

KW - BETA-2-ADRENERGIC RECEPTOR

KW - INFANTILE HEMANGIOMAS

KW - BETA-3-ADRENERGIC RECEPTORS

KW - FUNCTIONAL INVOLVEMENT

KW - VISUAL IMPAIRMENT

U2 - 10.1186/s12887-017-0923-8

DO - 10.1186/s12887-017-0923-8

M3 - Article

C2 - 28709412

VL - 17

JO - Bmc Pediatrics

JF - Bmc Pediatrics

SN - 1471-2431

M1 - 165

ER -