Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

Anouk W. Vaes*, Martijn A. Spruit, Karel Van Keer, Joao Barbosa-Breda, Emiel F. M. Wouters, Frits M. E. Franssen, Jan Theunis, Patrick De Boever

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (beta: -0.224; p=0.042 and beta: -0.136; p

Original languageEnglish
Article number31
Number of pages12
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 8 Jan 2020

Keywords

  • ATHEROSCLEROSIS RISK
  • VASCULAR CALIBER
  • CARDIOVASCULAR MORTALITY
  • SYSTEMIC INFLAMMATION
  • ENDOTHELIAL FUNCTION
  • PHYSICAL-ACTIVITY
  • DISEASE PATIENTS
  • HYPERTENSION
  • ARTERIOLAR
  • DIAMETERS

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