Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

Anouk W. Vaes; Martijn A. Spruit; Karel Van Keer; Joao Barbosa-Breda; Emiel F. M. Wouters; Frits M. E. Franssen; Jan Theunis; Patrick De Boever

doi:10.1038/s41598-019-56997-5

Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

Anouk W. Vaes^*, Martijn A. Spruit, Karel Van Keer, Joao Barbosa-Breda, Emiel F. M. Wouters, Frits M. E. Franssen, Jan Theunis, Patrick De Boever

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (beta: -0.224; p=0.042 and beta: -0.136; p

Original language	English
Article number	31
Number of pages	12
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-56997-5
Publication status	Published - 8 Jan 2020

Keywords

ATHEROSCLEROSIS RISK
VASCULAR CALIBER
CARDIOVASCULAR MORTALITY
SYSTEMIC INFLAMMATION
ENDOTHELIAL FUNCTION
PHYSICAL-ACTIVITY
DISEASE PATIENTS
HYPERTENSION
ARTERIOLAR
DIAMETERS

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Cite this

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title = "Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program",

abstract = "Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (beta: -0.224; p=0.042 and beta: -0.136; p",

keywords = "ATHEROSCLEROSIS RISK, VASCULAR CALIBER, CARDIOVASCULAR MORTALITY, SYSTEMIC INFLAMMATION, ENDOTHELIAL FUNCTION, PHYSICAL-ACTIVITY, DISEASE PATIENTS, HYPERTENSION, ARTERIOLAR, DIAMETERS",

author = "Vaes, {Anouk W.} and Spruit, {Martijn A.} and {Van Keer}, Karel and Joao Barbosa-Breda and Wouters, {Emiel F. M.} and Franssen, {Frits M. E.} and Jan Theunis and {De Boever}, Patrick",

note = "Funding Information: Study design. This was a prospective observational study conducted in Ciro (Horn, the Netherlands)69. The study was approved by the Medical Research Ethics Committees United (MEC-U, Nieuwegein, the Netherlands; NL56813.100.16). The study was performed in accordance with the tenets of the Declaration of Helsinki and Good Clinical Practice and has been registered on www.trialregister.nl (NTR5896) before enrolment of the first volunteering participant. All subjects gave written informed consent. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

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AU - Vaes, Anouk W.

AU - Spruit, Martijn A.

AU - Van Keer, Karel

AU - Barbosa-Breda, Joao

AU - Wouters, Emiel F. M.

AU - Franssen, Frits M. E.

AU - Theunis, Jan

AU - De Boever, Patrick

N1 - Funding Information: Study design. This was a prospective observational study conducted in Ciro (Horn, the Netherlands)69. The study was approved by the Medical Research Ethics Committees United (MEC-U, Nieuwegein, the Netherlands; NL56813.100.16). The study was performed in accordance with the tenets of the Declaration of Helsinki and Good Clinical Practice and has been registered on www.trialregister.nl (NTR5896) before enrolment of the first volunteering participant. All subjects gave written informed consent. Publisher Copyright: © 2020, The Author(s).

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N2 - Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (beta: -0.224; p=0.042 and beta: -0.136; p

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KW - DISEASE PATIENTS

KW - HYPERTENSION

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