Strenuous physical exercise adversely affects monocyte chemotaxis

Frauke S. Czepluch; Romain Barres; Kenneth Caidahl; Serve Olieslagers; Anna Krook; Anette Rickenlund; Juleen R. Zierath; Johannes Waltenberger

doi:10.1160/TH10-06-0363

Strenuous physical exercise adversely affects monocyte chemotaxis

Frauke S. Czepluch, Romain Barres, Kenneth Caidahl, Serve Olieslagers, Anna Krook, Anette Rickenlund, Juleen R. Zierath, Johannes Waltenberger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-beta 1 (TGF-beta 1) was completely inhibited immediately after training (p

Original language	English
Pages (from-to)	122-130
Journal	Thrombosis and Haemostasis
Volume	105
Issue number	1
DOIs	https://doi.org/10.1160/TH10-06-0363
Publication status	Published - Jan 2011

Keywords

Exercise
monocytes
chemotaxis
VEGF-A
TGF-beta 1

Access to Document

10.1160/TH10-06-0363

Cite this

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AU - Caidahl, Kenneth

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AU - Krook, Anna

AU - Rickenlund, Anette

AU - Zierath, Juleen R.

AU - Waltenberger, Johannes

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