Strenuous physical exercise adversely affects monocyte chemotaxis

Frauke S. Czepluch, Romain Barres, Kenneth Caidahl, Serve Olieslagers, Anna Krook, Anette Rickenlund, Juleen R. Zierath, Johannes Waltenberger*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)


Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-beta 1 (TGF-beta 1) was completely inhibited immediately after training (p
Original languageEnglish
Pages (from-to)122-130
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - Jan 2011


  • Exercise
  • monocytes
  • chemotaxis
  • VEGF-A
  • TGF-beta 1

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