Strategies for non-invasive management of high-grade cervical intraepithelial neoplasia: prognostic biomarkers and immunotherapy

Margot Maria Koeneman

Research output: ThesisDoctoral ThesisExternal prepared

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High-grade cervical intraepithelial neoplasia (CIN) is a precursor to cervical cancer. The surgical treatment strategy currently available increases the risk of preterm birth. This dissertation therefore examined two other treatment strategies. Because part of CIN disappears on its own, we first researched biomarkers (substances, patient characteristics) that could potentially be used for predictive purposes. Unfortunately, none of the markers we examined had any predictive value. We then researched whether imiquimod cream could serve as an alternative treatment method, which was met with enthusiasm from both gynaecologists and patients. We therefore tested the effectiveness and side effects of imiquimod cream in 120 female subjects. The results will be published soon.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Kruitwagen, Roy, Supervisor
  • Nijman, H. W., Supervisor, External person
  • Krüse, A.J., Co-Supervisor, External person
Award date16 Jan 2019
Place of PublicationMaastricht
Print ISBNs9789463324359
Publication statusPublished - 2019


  • CIN
  • Preterm birth
  • Predictive value
  • Imiquimod

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