High-grade cervical intraepithelial neoplasia (CIN) is a precursor to cervical cancer. The surgical treatment strategy currently available increases the risk of preterm birth. This dissertation therefore examined two other treatment strategies. Because part of CIN disappears on its own, we first researched biomarkers (substances, patient characteristics) that could potentially be used for predictive purposes. Unfortunately, none of the markers we examined had any predictive value. We then researched whether imiquimod cream could serve as an alternative treatment method, which was met with enthusiasm from both gynaecologists and patients. We therefore tested the effectiveness and side effects of imiquimod cream in 120 female subjects. The results will be published soon.
|Award date||16 Jan 2019|
|Place of Publication||Maastricht|
|Publication status||Published - 2019|
- Preterm birth
- Predictive value
Koeneman, M. M. (2019). Strategies for non-invasive management of high-grade cervical intraepithelial neoplasia: prognostic biomarkers and immunotherapy. Maastricht University. https://doi.org/10.26481/dis.20190116mk