Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks

R. Ganguly; P. Saha; S.L. Banerjee; A. Pich; N.K. Singha

doi:10.1002/marc.202100312

Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks

R. Ganguly, P. Saha, S.L. Banerjee, A. Pich^*, N.K. Singha^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe3+) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

Original language	English
Article number	2100312
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	42
Issue number	17
DOIs	https://doi.org/10.1002/marc.202100312
Publication status	Published - 1 Sept 2021

Keywords

cross-linked micelles
mussel-mimetics
pH-responsiveness
temperature-responsiveness
DUAL CROSS-LINKING
HYDROGEL
PH
POLYMERIZATION
MICROGELS
OXIDATION
POLYMERS
DELIVERY
BEHAVIOR
LCST

Access to Document

10.1002/marc.202100312

Cite this

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title = "Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks",

abstract = "Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe3+) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.",

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author = "R. Ganguly and P. Saha and S.L. Banerjee and A. Pich and N.K. Singha",

year = "2021",

month = sep,

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doi = "10.1002/marc.202100312",

language = "English",

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publisher = "Wiley-VCH Verlag",

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T1 - Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks

AU - Ganguly, R.

AU - Saha, P.

AU - Banerjee, S.L.

AU - Pich, A.

AU - Singha, N.K.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe3+) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

AB - Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe3+) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

KW - cross-linked micelles

KW - mussel-mimetics

KW - pH-responsiveness

KW - temperature-responsiveness

KW - DUAL CROSS-LINKING

KW - HYDROGEL

KW - PH

KW - POLYMERIZATION

KW - MICROGELS

KW - OXIDATION

KW - POLYMERS

KW - DELIVERY

KW - BEHAVIOR

KW - LCST

U2 - 10.1002/marc.202100312

DO - 10.1002/marc.202100312

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JO - Macromolecular Rapid Communications

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