Stereotactic Body Radiation Therapy for Extracranial Oligometastatic Non-small-cell Lung Cancer: A Systematic Review

May N. Tsao*, Lieke In 't Ven, Patrick Cheung, Ian Poon, Yee Ung, Alexander Louie

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Stereotactic body radiation therapy (SBRT) has emerged as a treatment modality for selected patients with oligometastatic nonesmall-cell lung cancer (NSCLC). The objectives of this systematic review were to explore the benefits and risks of SBRT for extracranial oligometastatic NSCLC.The MEDLINE, Embase, PubMed, and CENTRAL databases were searched for relevant articles from January 1, 2000 to July 23, 2019. Fully published phase III or phase II trials of any sample size were included. Retrospective series published in manuscript form with at least 50 patients were also included. Four prospective phase II randomized trials (total, 188 participants), 4 prospective non-randomized studies (total, 140 participants), and eleven retrospective studies (total, 1288 participants) were included in this systematic review. A variety of dose fractionation schemes were used. The median overall survival (OS) ranged from 13.5 to 55 months. Progression-free survival (PFS) ranged from 4.4 to 14.7 months. Quality of life outcomes were reported in 2 studies. None of the studies reported symptom control outcomes.There are no fully completed phase III randomized trials that clarify the risks and benefits of SBRT for oligometastatic NSCLC. Higher PFS and OS with SBRT were reported in 4 phase II randomized studies. The results from mature phase III randomized data regarding whether SBRT for oligometastatic NSCLC benefits patients in terms of OS, PFS, quality of life, and symptom control are needed.

Original languageEnglish
Pages (from-to)95-105.e1
Number of pages11
JournalClinical Lung Cancer
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Chest
  • Malignancy
  • Metastatic
  • SBRT
  • Summary
  • PHASE-II-TRIAL
  • ABLATIVE RADIOTHERAPY
  • PROGNOSTIC-FACTORS
  • RADICAL TREATMENT
  • LOCAL TREATMENT
  • POOLED ANALYSIS
  • METASTASES
  • PATTERNS
  • SURVIVAL
  • OUTCOMES
  • Sbrt

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