Staged Mucosal Advancement Flap versus Staged Fibrin Sealant in the Treatment of Complex Perianal Fistulas.

S.J. van der Hagen; C.G.M.I. Baeten; P.B. Soeters; W.G. van Gemert

doi:10.1155/2011/186350

Staged Mucosal Advancement Flap versus Staged Fibrin Sealant in the Treatment of Complex Perianal Fistulas.

S.J. van der Hagen^*, C.G.M.I. Baeten, P.B. Soeters, W.G. van Gemert

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background. In this prospective randomised study, the staged mucosal advancement flap is compared with staged fibrin sealant application in the treatment of perianal fistulas. Methods. All patients with high complex cryptoglandular fistulas were randomised to closure of the internal opening by a mucosal advancement flap (MF) or injection with fibrin sealant (FS) after treatment with setons. Recurrence rate and incontinence disorders were explored. Results. The MF group (5 females and 10 males) with a median age of 51 years and a median followup of 52 months. The FS group (4 females and 11 males) with a median age of 45 years and a median followup of 49 months. Three (20%) patients of the MF group had a recurrent fistula compared to 9 (60%) of the FS group (P = 0.03). No new continence disorders developed. Conclusion. Staged FS injection has a much lower success rate compared to MF.

Original language	English
Number of pages	7
Journal	Gastroenterology research and practice
DOIs	https://doi.org/10.1155/2011/186350
Publication status	Published - 1 Jan 2011

Keywords

ANAL FISTULA
TRANSSPHINCTERIC FISTULAS
ANORECTAL FISTULAS
GLUE TREATMENT
RISK-FACTORS
REPAIR
SMOKING
TRIAL
MANAGEMENT
EFFICACY

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Cite this

@article{99dba80e62c840d08cf8ac44989e5176,

title = "Staged Mucosal Advancement Flap versus Staged Fibrin Sealant in the Treatment of Complex Perianal Fistulas.",

abstract = "Background. In this prospective randomised study, the staged mucosal advancement flap is compared with staged fibrin sealant application in the treatment of perianal fistulas. Methods. All patients with high complex cryptoglandular fistulas were randomised to closure of the internal opening by a mucosal advancement flap (MF) or injection with fibrin sealant (FS) after treatment with setons. Recurrence rate and incontinence disorders were explored. Results. The MF group (5 females and 10 males) with a median age of 51 years and a median followup of 52 months. The FS group (4 females and 11 males) with a median age of 45 years and a median followup of 49 months. Three (20%) patients of the MF group had a recurrent fistula compared to 9 (60%) of the FS group (P = 0.03). No new continence disorders developed. Conclusion. Staged FS injection has a much lower success rate compared to MF.",

keywords = "ANAL FISTULA, TRANSSPHINCTERIC FISTULAS, ANORECTAL FISTULAS, GLUE TREATMENT, RISK-FACTORS, REPAIR, SMOKING, TRIAL, MANAGEMENT, EFFICACY",

author = "{van der Hagen}, S.J. and C.G.M.I. Baeten and P.B. Soeters and {van Gemert}, W.G.",

year = "2011",

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doi = "10.1155/2011/186350",

language = "English",

journal = "Gastroenterology research and practice",

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T1 - Staged Mucosal Advancement Flap versus Staged Fibrin Sealant in the Treatment of Complex Perianal Fistulas.

AU - van der Hagen, S.J.

AU - Baeten, C.G.M.I.

AU - Soeters, P.B.

AU - van Gemert, W.G.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background. In this prospective randomised study, the staged mucosal advancement flap is compared with staged fibrin sealant application in the treatment of perianal fistulas. Methods. All patients with high complex cryptoglandular fistulas were randomised to closure of the internal opening by a mucosal advancement flap (MF) or injection with fibrin sealant (FS) after treatment with setons. Recurrence rate and incontinence disorders were explored. Results. The MF group (5 females and 10 males) with a median age of 51 years and a median followup of 52 months. The FS group (4 females and 11 males) with a median age of 45 years and a median followup of 49 months. Three (20%) patients of the MF group had a recurrent fistula compared to 9 (60%) of the FS group (P = 0.03). No new continence disorders developed. Conclusion. Staged FS injection has a much lower success rate compared to MF.

AB - Background. In this prospective randomised study, the staged mucosal advancement flap is compared with staged fibrin sealant application in the treatment of perianal fistulas. Methods. All patients with high complex cryptoglandular fistulas were randomised to closure of the internal opening by a mucosal advancement flap (MF) or injection with fibrin sealant (FS) after treatment with setons. Recurrence rate and incontinence disorders were explored. Results. The MF group (5 females and 10 males) with a median age of 51 years and a median followup of 52 months. The FS group (4 females and 11 males) with a median age of 45 years and a median followup of 49 months. Three (20%) patients of the MF group had a recurrent fistula compared to 9 (60%) of the FS group (P = 0.03). No new continence disorders developed. Conclusion. Staged FS injection has a much lower success rate compared to MF.

KW - ANAL FISTULA

KW - TRANSSPHINCTERIC FISTULAS

KW - ANORECTAL FISTULAS

KW - GLUE TREATMENT

KW - RISK-FACTORS

KW - REPAIR

KW - SMOKING

KW - TRIAL

KW - MANAGEMENT

KW - EFFICACY

U2 - 10.1155/2011/186350

DO - 10.1155/2011/186350

M3 - Article

C2 - 21808642

SN - 1687-6121

JO - Gastroenterology research and practice

JF - Gastroenterology research and practice

ER -