TY - JOUR
T1 - Sports participation and physical activity in patients with von Willebrand disease
AU - Atiq, Ferdows
AU - Mauser-Bunschoten, Eveline P.
AU - Eikenboom, Jeroen
AU - van Galen, Karin P. M.
AU - Meijer, Karina
AU - de Meris, Joke
AU - Cnossen, Marjon H.
AU - Beckers, Erick A. M.
AU - Laros-van Gorkom, Britta A. P.
AU - Nieuwenhuizen, Laurens
AU - van der Bom, Johanna G.
AU - Fijnvandraat, Karin
AU - Leebeek, Frank W. G.
AU - WiN Study Group
N1 - Funding Information:
This study was supported (in part) by research funding from the Dutch Hemophilia Foundation (Stichting Haemophilia) and CSL Behring (unrestricted grant).
Funding Information:
This study was supported (in part) by research funding Dutch Hemophilia Foundation (Stichting Haemophilia) Behring (unrestricted grant).
Publisher Copyright:
© 2018 The Authors. Haemophilia Published by John Wiley & Sons Ltd
PY - 2019/1
Y1 - 2019/1
N2 - Introduction Patients with bleeding disorders may experience limitations in sports participation and physical activity. Several studies on sports participation have been performed in haemophilia patients, but studies in patients with von Willebrand disease (VWD) are lacking. Aim We assessed the sports participation and physical activity of a large cohort of VWD patients. Methods Patients were included from the "WiN study." All patients completed a questionnaire on sports participation, physical activity, quality of life and bleeding symptoms (Tosetto bleeding score). Results From the 798 included patients, 474 had type 1, 301 type 2 and 23 type 3 VWD. The mean age was 39 +/- 20 (standard deviation) years. Five hundred and fifty-two patients (69.3%) participated in various types of sports. Type 3 VWD patients more often did not participate in sports due to fear of bleeding and physical impairment, respectively, OR = 13.24 (95% CI: 2.45-71.53) and OR = 5.90 (95% CI: 1.77-19.72). Patients who did not participate in sports due to physical impairment had a higher bleeding score item for joint bleeds 1.0 (+/- 1.6) vs 0.5 (+/- 1.1) (P = 0.036). Patients with type 3 VWD and patients with a higher bleeding score frequently had severe limitations during daily activities, respectively, OR = 9.84 (95% CI: 2.83-34.24) and OR = 1.08 (95% CI: 1.04-1.12). Conclusion The majority of VWD patients participated in sports. Patients with type 3 VWD, a history of joint bleeds and a more severe bleeding phenotype frequently experienced limitations in sports participation and physical activities during daily life.
AB - Introduction Patients with bleeding disorders may experience limitations in sports participation and physical activity. Several studies on sports participation have been performed in haemophilia patients, but studies in patients with von Willebrand disease (VWD) are lacking. Aim We assessed the sports participation and physical activity of a large cohort of VWD patients. Methods Patients were included from the "WiN study." All patients completed a questionnaire on sports participation, physical activity, quality of life and bleeding symptoms (Tosetto bleeding score). Results From the 798 included patients, 474 had type 1, 301 type 2 and 23 type 3 VWD. The mean age was 39 +/- 20 (standard deviation) years. Five hundred and fifty-two patients (69.3%) participated in various types of sports. Type 3 VWD patients more often did not participate in sports due to fear of bleeding and physical impairment, respectively, OR = 13.24 (95% CI: 2.45-71.53) and OR = 5.90 (95% CI: 1.77-19.72). Patients who did not participate in sports due to physical impairment had a higher bleeding score item for joint bleeds 1.0 (+/- 1.6) vs 0.5 (+/- 1.1) (P = 0.036). Patients with type 3 VWD and patients with a higher bleeding score frequently had severe limitations during daily activities, respectively, OR = 9.84 (95% CI: 2.83-34.24) and OR = 1.08 (95% CI: 1.04-1.12). Conclusion The majority of VWD patients participated in sports. Patients with type 3 VWD, a history of joint bleeds and a more severe bleeding phenotype frequently experienced limitations in sports participation and physical activities during daily life.
KW - physical activity
KW - quality of life
KW - sports
KW - von Willebrand disease
KW - QUALITY-OF-LIFE
KW - ADULT PATIENTS
KW - CHILDREN
KW - ADOLESCENTS
KW - MODERATE
KW - RECOMMENDATIONS
KW - CLASSIFICATION
KW - HEMOPHILIA
U2 - 10.1111/hae.13629
DO - 10.1111/hae.13629
M3 - Article
C2 - 30427095
SN - 1351-8216
VL - 25
SP - 101
EP - 108
JO - Haemophilia
JF - Haemophilia
IS - 1
ER -