SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols

Ami Baba; Maureen Smith; Beth K. Potter; An Wen Chan; David Moher; Alene Toulany; Amanda Doherty-Kirby; Begonya Nafria Escalera; Catherine Stratton; Chris Gale; Colin Macarthur; Diane Purper-Ouakil; Edmund Juszczak; Eyal Cohen; Giorgio Reggiardo; Jennifer Preston; Jérémie F. Cohen; Julia Upton; Karel Allegaert; Katelynn Boerner; Kayur Mehta; Kim An Nguyen; Kimberly Courtney; Lisa Hartling; Menelaos Konstantinidis; Michal Odermarsky; Nancy J. Butcher; Niina Kolehmainen; Patricia E. Longmuir; Peter J. Gill; Piet Leroy; Reinhard Feneberg; Ramesh Poluru; Shaun K. Morris; Stefan J. Friedrichsdorf; Tanya Chute Nagy; Terry P. Klassen; Thierry Lacaze-Masmonteil; Wes Onland; Martin Offringa

doi:10.1136/bmj-2025-085062

SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols

Ami Baba
, Maureen Smith
, Beth K. Potter
, An Wen Chan
, David Moher
, Alene Toulany
, Amanda Doherty-Kirby
, Begonya Nafria Escalera
, Catherine Stratton
, Chris Gale
, Colin Macarthur
, Diane Purper-Ouakil
, Edmund Juszczak
, Eyal Cohen
, Giorgio Reggiardo
, Jennifer Preston
, Jérémie F. Cohen
, Julia Upton
, Karel Allegaert
, Katelynn Boerner

Kayur Mehta, Kim An Nguyen, Kimberly Courtney, Lisa Hartling, Menelaos Konstantinidis, Michal Odermarsky, Nancy J. Butcher, Niina Kolehmainen, Patricia E. Longmuir, Peter J. Gill, Piet Leroy, Reinhard Feneberg, Ramesh Poluru, Shaun K. Morris, Stefan J. Friedrichsdorf, Tanya Chute Nagy, Terry P. Klassen, Thierry Lacaze-Masmonteil, Wes Onland, Martin Offringa

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	e085062
Journal	BMJ
Volume	392
DOIs	https://doi.org/10.1136/bmj-2025-085062
Publication status	Published - 24 Feb 2026

Access to Document

10.1136/bmj-2025-085062Licence: Other

Cite this

Baba, A., Smith, M., Potter, B. K., Chan, A. W., Moher, D., Toulany, A., Doherty-Kirby, A., Nafria Escalera, B., Stratton, C., Gale, C., Macarthur, C., Purper-Ouakil, D., Juszczak, E., Cohen, E., Reggiardo, G., Preston, J., Cohen, J. F., Upton, J., Allegaert, K., ... Offringa, M. (2026). SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols. BMJ, 392, e085062. https://doi.org/10.1136/bmj-2025-085062

@article{6d9b38679b414961bd3f07bd902a60b5,

title = "SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols",

author = "Ami Baba and Maureen Smith and Potter, \{Beth K.\} and Chan, \{An Wen\} and David Moher and Alene Toulany and Amanda Doherty-Kirby and \{Nafria Escalera\}, Begonya and Catherine Stratton and Chris Gale and Colin Macarthur and Diane Purper-Ouakil and Edmund Juszczak and Eyal Cohen and Giorgio Reggiardo and Jennifer Preston and Cohen, \{J{\'e}r{\'e}mie F.\} and Julia Upton and Karel Allegaert and Katelynn Boerner and Kayur Mehta and Nguyen, \{Kim An\} and Kimberly Courtney and Lisa Hartling and Menelaos Konstantinidis and Michal Odermarsky and Butcher, \{Nancy J.\} and Niina Kolehmainen and Longmuir, \{Patricia E.\} and Gill, \{Peter J.\} and Piet Leroy and Reinhard Feneberg and Ramesh Poluru and Morris, \{Shaun K.\} and Friedrichsdorf, \{Stefan J.\} and \{Chute Nagy\}, Tanya and Klassen, \{Terry P.\} and Thierry Lacaze-Masmonteil and Wes Onland and Martin Offringa",

year = "2026",

month = feb,

day = "24",

doi = "10.1136/bmj-2025-085062",

language = "English",

volume = "392",

pages = "e085062",

journal = "BMJ",

issn = "0959-8146",

publisher = "BMJ Publishing Group",

}

Baba, A, Smith, M, Potter, BK, Chan, AW, Moher, D, Toulany, A, Doherty-Kirby, A, Nafria Escalera, B, Stratton, C, Gale, C, Macarthur, C, Purper-Ouakil, D, Juszczak, E, Cohen, E, Reggiardo, G, Preston, J, Cohen, JF, Upton, J, Allegaert, K, Boerner, K, Mehta, K, Nguyen, KA, Courtney, K, Hartling, L, Konstantinidis, M, Odermarsky, M, Butcher, NJ, Kolehmainen, N, Longmuir, PE, Gill, PJ, Leroy, P, Feneberg, R, Poluru, R, Morris, SK, Friedrichsdorf, SJ, Chute Nagy, T, Klassen, TP, Lacaze-Masmonteil, T, Onland, W & Offringa, M 2026, 'SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols', BMJ, vol. 392, pp. e085062. https://doi.org/10.1136/bmj-2025-085062

TY - JOUR

T1 - SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement

T2 - enhancing the reporting and usefulness of paediatric randomised trial protocols

AU - Baba, Ami

AU - Smith, Maureen

AU - Potter, Beth K.

AU - Chan, An Wen

AU - Moher, David

AU - Toulany, Alene

AU - Doherty-Kirby, Amanda

AU - Nafria Escalera, Begonya

AU - Stratton, Catherine

AU - Gale, Chris

AU - Macarthur, Colin

AU - Purper-Ouakil, Diane

AU - Juszczak, Edmund

AU - Cohen, Eyal

AU - Reggiardo, Giorgio

AU - Preston, Jennifer

AU - Cohen, Jérémie F.

AU - Upton, Julia

AU - Allegaert, Karel

AU - Boerner, Katelynn

AU - Mehta, Kayur

AU - Nguyen, Kim An

AU - Courtney, Kimberly

AU - Hartling, Lisa

AU - Konstantinidis, Menelaos

AU - Odermarsky, Michal

AU - Butcher, Nancy J.

AU - Kolehmainen, Niina

AU - Longmuir, Patricia E.

AU - Gill, Peter J.

AU - Leroy, Piet

AU - Feneberg, Reinhard

AU - Poluru, Ramesh

AU - Morris, Shaun K.

AU - Friedrichsdorf, Stefan J.

AU - Chute Nagy, Tanya

AU - Klassen, Terry P.

AU - Lacaze-Masmonteil, Thierry

AU - Onland, Wes

AU - Offringa, Martin

PY - 2026/2/24

Y1 - 2026/2/24

U2 - 10.1136/bmj-2025-085062

DO - 10.1136/bmj-2025-085062

M3 - Article

SN - 0959-8146

VL - 392

SP - e085062

JO - BMJ

JF - BMJ

ER -