Abstract
BackgroundDownstream remodeling of the spiral arteries (SpA) decreases utero-placental resistance drastically, allowing sustained and increased blood flow to the placenta under all circumstances. We systematically evaluated available reports to visualize adaptation of spiral arteries throughout pregnancy by ultra-sonographic measurements and evaluated when this process is completed.MethodsA systematic review and meta-analysis of spiral artery flow (pulsatility index (PI), resistance index (RI) and peak systolic velocity (PSV)) was performed. English written articles were obtained from Pubmed, EMBASE and Cochrane Library and included articles were assessed on quality and risk of bias. Weighted means of Doppler indices were calculated using a random-effects model.ResultsIn healthy pregnancies, PI and RI decreased from 0.80 (95% CI: 0.70-0.89) and 0.50 (95% CI: 0.47-0.54) in the first trimester to 0.50 (95% CI: 0.45-0.55, p
Original language | English |
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Article number | 680 |
Number of pages | 15 |
Journal | BMC Pregnancy and Childbirth |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - 11 Nov 2020 |
Keywords
- Spiral artery
- Doppler
- Pregnancy
- Adaptation
- Remodeling
- 1ST TRIMESTER UTERINE
- UTEROPLACENTAL CIRCULATION
- TROPHOBLASTIC INVASION
- DOPPLER MEASUREMENTS
- OXIDATIVE STRESS
- HEMODYNAMICS
- PREDICTION
- REPRODUCIBILITY
- PREECLAMPSIA
- RESTRICTION