Spiral artery blood flow during pregnancy: a systematic review and meta-analysis

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

BackgroundDownstream remodeling of the spiral arteries (SpA) decreases utero-placental resistance drastically, allowing sustained and increased blood flow to the placenta under all circumstances. We systematically evaluated available reports to visualize adaptation of spiral arteries throughout pregnancy by ultra-sonographic measurements and evaluated when this process is completed.MethodsA systematic review and meta-analysis of spiral artery flow (pulsatility index (PI), resistance index (RI) and peak systolic velocity (PSV)) was performed. English written articles were obtained from Pubmed, EMBASE and Cochrane Library and included articles were assessed on quality and risk of bias. Weighted means of Doppler indices were calculated using a random-effects model.ResultsIn healthy pregnancies, PI and RI decreased from 0.80 (95% CI: 0.70-0.89) and 0.50 (95% CI: 0.47-0.54) in the first trimester to 0.50 (95% CI: 0.45-0.55, p

Original languageEnglish
Article number680
Number of pages15
JournalBMC Pregnancy and Childbirth
Volume20
Issue number1
DOIs
Publication statusPublished - 11 Nov 2020

Keywords

  • Spiral artery
  • Doppler
  • Pregnancy
  • Adaptation
  • Remodeling
  • 1ST TRIMESTER UTERINE
  • UTEROPLACENTAL CIRCULATION
  • TROPHOBLASTIC INVASION
  • DOPPLER MEASUREMENTS
  • OXIDATIVE STRESS
  • HEMODYNAMICS
  • PREDICTION
  • REPRODUCIBILITY
  • PREECLAMPSIA
  • RESTRICTION

Fingerprint

Dive into the research topics of 'Spiral artery blood flow during pregnancy: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this