Spectral decomposition of susceptibility artifacts for spectral-spatial radiofrequency pulse design

Cungeng Yang, Benedikt A Poser, Weiran Deng, V Andrew Stenger

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Susceptibility induced signal loss is a limitation in gradient echo functional MRI. The through-plane artifact in axial slices is particularly problematic due to the inferior position of air cavities in the brain. Spectral-spatial radiofrequency pulses have recently been shown to reduce signal loss in a single excitation. The pulses were successfully demonstrated assuming a linear relationship between susceptibility gradient and frequency, however, the exact frequency and spatial distribution of the susceptibility gradient in the brain is unknown. We present a spiral spectroscopic imaging sequence with a time-shifted radiofrequency pulse that can spectrally decompose the through-plane susceptibility gradient for spectral-spatial radiofrequency pulse design. Maps of the through-plane susceptibility gradient as a function of frequency were generated for the human brain at 3T. We found that the linear relationship holds well for the whole brain with an optimal slope of -1.0 μT/m/Hz.

Original languageEnglish
Pages (from-to)1905-1910
Number of pages6
JournalMagnetic Resonance in Medicine
Volume68
Issue number6
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Keywords

  • Algorithms
  • Artifacts
  • Brain
  • Brain Mapping
  • Humans
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Radio Waves
  • Reproducibility of Results
  • Sensitivity and Specificity

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