Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients

R. D. van Anholt*, L. Sobotka, E. P. Meijer, H. Heyman, H. W. Groen, Eva Topinkova, M. van Leen, J. M. G. A. Schols

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: We investigated the potential of a high-protein, arginine- and micronutrient-enriched oral nutritional supplement (ONS) to improve healing of pressure ulcers in non-malnourished patients who would usually not be considered for extra nutritional support. Methods: Forty-three non-malnourished subjects with stage III or IV pressure ulcers were included in a multicountry, randomized, controlled, double-blind, parallel group trial. They were offered 200 mL of the specific ONS or a non-caloric control product three times per day, in addition to their regular diet and standard wound care, for a maximum of 8 wk. Results were compared with repeated-measures mixed models (RMMM), analysis of variance, or Fisher's exact tests for categorical parameters. Results: Supplementation with the specific ONS accelerated pressure ulcer healing, indicated by a significantly different decrease in ulcer size compared with the control, over the period of 8 wk (P
Original languageEnglish
Pages (from-to)867-872
Issue number9
Publication statusPublished - Sept 2010


  • Pressure ulcers
  • Oral nutritional supplement
  • Non-malnourished
  • Protein
  • Arginine
  • Zinc
  • Vitamins

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