Spatially resolved proteomics in osteoarthritis: State of the art and new perspectives

M. R. Eveque-Mourroux, B. Rocha, F. P. Y. Barre, R. M. A. Heeren, B. Cillero-Pastor*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Web of Science)

Abstract

Osteoarthritis (OA) is one of the most common diseases worldwide caused by chronic degeneration of the joints. Its high prevalence and the involvement of several tissues define OA as a highly heterogeneous disease. New biological markers to evaluate the progression of the pathology and improve its prognosis are needed. Among all the different-omic strategies applied to OA, solution phase bottom-up proteomics has made an extensive contribution to the field of biomarker research. However, new technologies for protein analysis should be considered for a better understanding of the disease. This review focuses on complementary proteomic methodologies and new technologies for translational research of OA and other rheumatic pathologies, especially mass spectrometry imaging and protein imaging methods not applied by the OA community yet.

Original languageEnglish
Article number103637
Number of pages7
JournalJournal of Proteomics
Volume215
DOIs
Publication statusPublished - 20 Mar 2020

Keywords

  • Osteoarthritis
  • Proteomics
  • Molecular imaging
  • Spatially resolved
  • LASER CAPTURE MICRODISSECTION
  • IMAGING MASS-SPECTROMETRY
  • SYNOVIAL-FLUID
  • OSTEOCHONDRAL JUNCTION
  • EXTRACELLULAR-MATRIX
  • HUMAN INTERACTOME
  • SUBCHONDRAL BONE
  • N-GLYCANS
  • TOP-DOWN
  • TISSUE

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