Spatial Relationship Between Atrial Fibrillation Drivers and the Presence of Repetitive Conduction Patterns Using Recurrence Analysis on In-Silico Models

Victor Gonçalves Marques*, A. Gharaviri, S. Pezzuto, Pietro Bonizzi, Stef Zeemering, Ulrich Schotten

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

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Abstract

Catheter ablation treatment for atrial fibrillation (AF) is still suboptimal, possibly due to the difficulty to identify AF drivers. Recurrence analysis can be used to detect and eventually locate repetitive patterns that tend to be generated by AF drivers. In this study, we aimed to understand the spatial relationship between repetitiveness in recurrence analysis and rotor positions in an in-silico AF model. AF was simulated in a detailed three-dimensional model of the atria considering different degrees of endomysial fibrosis (0% and 70%). Rotors driving AF were tracked based on phase singularities obtained from transmembrane potentials. Activation-phase signals calculated from electrograms (4×4 electrode grid, 3 mm spacing) were used for recurrence analysis. Intervals with and without long-lasting sources inside the electrode coverage area were determined; the recurrence in both groups of intervals was quantified and compared with each other by calculating the recurrence rate (RR) per AF cycle length. RRs were lower during intervals with sources for both 0% and 70% fibrosis groups (0.56 [0.36;0.85] vs. 0.90 [0.80;0.97], p < 0.001 and 0.73 [0.41;0.84] vs. 0.87 [0.76;0.92], p < 0.001, respectively). These results indicate that recurrences are found in the area adjacent to the sources but not on the sources themselves, thus suggesting that recurrence analysis could contribute to guide ablation therapy.

Original languageEnglish
Title of host publication2021 Computing in Cardiology (CinC)
PublisherIEEE
Pages1-4
Number of pages4
ISBN (Electronic)9781665479165
ISBN (Print)978-1-6654-6721-6
DOIs
Publication statusPublished - 2021
Event2021 Computing in Cardiology (CinC) - Brno, Czech Republic, Brno, Czech Republic
Duration: 13 Sept 202115 Sept 2021
http://www.cinc2021.org/

Publication series

SeriesComputing in Cardiology
Volume48
ISSN2325-8861

Conference

Conference2021 Computing in Cardiology (CinC)
Country/TerritoryCzech Republic
CityBrno
Period13/09/2115/09/21
Internet address

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