Abstract
Catheter ablation treatment for atrial fibrillation (AF) is still suboptimal, possibly due to the difficulty to identify AF drivers. Recurrence analysis can be used to detect and eventually locate repetitive patterns that tend to be generated by AF drivers. In this study, we aimed to understand the spatial relationship between repetitiveness in recurrence analysis and rotor positions in an in-silico AF model. AF was simulated in a detailed three-dimensional model of the atria considering different degrees of endomysial fibrosis (0% and 70%). Rotors driving AF were tracked based on phase singularities obtained from transmembrane potentials. Activation-phase signals calculated from electrograms (4×4 electrode grid, 3 mm spacing) were used for recurrence analysis. Intervals with and without long-lasting sources inside the electrode coverage area were determined; the recurrence in both groups of intervals was quantified and compared with each other by calculating the recurrence rate (RR) per AF cycle length. RRs were lower during intervals with sources for both 0% and 70% fibrosis groups (0.56 [0.36;0.85] vs. 0.90 [0.80;0.97], p < 0.001 and 0.73 [0.41;0.84] vs. 0.87 [0.76;0.92], p < 0.001, respectively). These results indicate that recurrences are found in the area adjacent to the sources but not on the sources themselves, thus suggesting that recurrence analysis could contribute to guide ablation therapy.
Original language | English |
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Title of host publication | 2021 Computing in Cardiology (CinC) |
Publisher | IEEE |
Pages | 1-4 |
Number of pages | 4 |
ISBN (Electronic) | 9781665479165 |
ISBN (Print) | 978-1-6654-6721-6 |
DOIs | |
Publication status | Published - 2021 |
Event | 2021 Computing in Cardiology (CinC) - Brno, Czech Republic, Brno, Czech Republic Duration: 13 Sept 2021 → 15 Sept 2021 http://www.cinc2021.org/ |
Publication series
Series | Computing in Cardiology |
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Volume | 48 |
ISSN | 2325-8861 |
Conference
Conference | 2021 Computing in Cardiology (CinC) |
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Country/Territory | Czech Republic |
City | Brno |
Period | 13/09/21 → 15/09/21 |
Internet address |