Spatial inhomogeneity of common carotid artery intima media is increased in dialysis patients and is independently related to antibodies to oxidized-LDL and serum fetuin-A concentration

M.M.H. Hermans, J.P. Kooman, J.M. Meinders, F.M. van der Sande, V. Brandenburg, M. Ketteler, J.G.M.C. Damoiseaux, J.W. Cohen Tervaert, I. Ferreira, C.J.A.M. Konings, P.L. Rensma, U. Gladziwa, A.A. Kroon, A.P.G. Hoeks, C.D.A. Stehouwer, K.M.L. Leunissen

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Abstract

Background. Structural abnormalities of the common carotid artery (CCA), as assessed by ultrasound techniques, are related to cardiovascular outcome in dialysis patients. An increased intima media thickness (IMT) of the CCA may both represent a reaction to a haemodynamic burden as well as atherosclerosis. With a new ultrasound technique CCA-IMT and IMT-inhomogeneity, a novel parameter of spatial variance of the IMT, were measured and related to traditional and non-traditional risk factors. Methods. In a cross-sectional study, we included 134 dialysis patients, aged 61 +/- 13 years (103 on haemodialysis, 31 on peritoneal dialysis) and 41 controls, aged 60 +/- 8 years. Age, sex, pulse pressure, diabetes, prevalent cardiovascular disease (CVD) and height were included in the basic multiregression analysis. Ultrasound examination of the CCA was performed. We also measured serum fetuin-A, high-sensitivity C-reactive protein (hsCRP), antibodies to oxidized low density lipoproteins (anti-oxLDL antibodies), calcium, phosphate, albumin and parathyroid hormone. Results. Compared with controls, dialysis patients had a greater CCA-IMT (670 mu m vs 590 +/- 10 mu m; P = 0.002) and a greater CCA-IMT inhomogeneity (11.0 vs 8.1%; P = 0.013). Dialysis patients with CVD had a greater CCA-IMT (734 mu m vs 631 mu m; P = 0.001) and IMT-inhomogeneity (13.2 vs 9.7; P = 0.008) compared with patients without CVD. IMT-inhomogeneity strongly correlated with IMT (R = 0.65, P entities.
Original languageEnglish
Pages (from-to)1205-1212
JournalNephrology Dialysis Transplantation
Volume22 (4)
DOIs
Publication statusPublished - 1 Jan 2007

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