Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes

Keyphrases

• Haploinsufficiency 100%
• Missense mutation 100%
• Neurodevelopmental Disorders 100%
• Associated Genes 100%
• Spatial Clustering 100%
• Intellectual Disability 40%
• Intellectual Developmental Disorder 40%
• De-novo mutations 20%
• Exome 20%
• Genetic Variation 20%
• Large Cohort 20%
• Identified Genes 20%
• Dominant Negative 20%
• Protein Structure 20%
• Gain-of-function 20%
• Intolerance 20%
• Structural Integrity 20%
• Dominant mutation 20%
• Mutation Strategy 20%
• Neuronal Processes 20%
• 3D Modeling 20%
• Spatial Clustering Pattern 20%

Biochemistry, Genetics and Molecular Biology

• Missense Mutation 100%
• Haploinsufficiency 100%
• Intellectual Disability 40%
• Genetic Variation 20%
• Genetic Divergence 20%
• Protein Structure 20%
• Exome 20%

INIS

• genes 100%
• mutations 100%
• diseases 9%
• comparative evaluations 9%
• variations 9%
• gain 9%
• dominant mutations 9%
• modeling 9%
• datasets 9%
• genetics 9%
• protein structure 9%