Somatostatin Receptor Imaging-Guided Pasireotide Therapy in Medullary Thyroid Cancer With Ectopic Adrenocorticotropin Production

Frederik A. Verburg; Martin Anlauf; Felix M. Mottaghy; Wolfram Karges

doi:10.1097/RLU.0000000000000522

Somatostatin Receptor Imaging-Guided Pasireotide Therapy in Medullary Thyroid Cancer With Ectopic Adrenocorticotropin Production

Frederik A. Verburg^*, Martin Anlauf, Felix M. Mottaghy, Wolfram Karges

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

A 51-year-old man with a history of metastatic medullary thyroid cancer (MTC) presented with high adrenocorticotropin (ACTH) and urinary free cortisol levels. The diagnosis of ectopic ACTH production, a rare MTC complication, was established in this patient. PET/CT using the somatostatin analogue DOTA-(Tyr)-octreotate labeled with gallium (Ga-DOTATATE) was performed, showing positive radionuclide uptake in multiple MTC metastases. After this therapy with the novel somatostatin analogue, pasireotide was initiated after which urinary free cortisol and ACTH levels decreased. The present case thus illustrates a potential theranostic use of Ga-DOTATATE PET/CT in MTC.

Original language	English
Pages (from-to)	E83-E84
Journal	Clinical Nuclear Medicine
Volume	40
Issue number	1
DOIs	https://doi.org/10.1097/RLU.0000000000000522
Publication status	Published - Jan 2015

Keywords

somatostatin receptor
Ga-68-DOTATATE
PET/CT
pasireotide

Access to Document

10.1097/RLU.0000000000000522

Cite this

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title = "Somatostatin Receptor Imaging-Guided Pasireotide Therapy in Medullary Thyroid Cancer With Ectopic Adrenocorticotropin Production",

abstract = "A 51-year-old man with a history of metastatic medullary thyroid cancer (MTC) presented with high adrenocorticotropin (ACTH) and urinary free cortisol levels. The diagnosis of ectopic ACTH production, a rare MTC complication, was established in this patient. PET/CT using the somatostatin analogue DOTA-(Tyr)-octreotate labeled with gallium (Ga-DOTATATE) was performed, showing positive radionuclide uptake in multiple MTC metastases. After this therapy with the novel somatostatin analogue, pasireotide was initiated after which urinary free cortisol and ACTH levels decreased. The present case thus illustrates a potential theranostic use of Ga-DOTATATE PET/CT in MTC.",

keywords = "somatostatin receptor, Ga-68-DOTATATE, PET/CT, pasireotide",

author = "Verburg, {Frederik A.} and Martin Anlauf and Mottaghy, {Felix M.} and Wolfram Karges",

year = "2015",

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volume = "40",

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T1 - Somatostatin Receptor Imaging-Guided Pasireotide Therapy in Medullary Thyroid Cancer With Ectopic Adrenocorticotropin Production

AU - Verburg, Frederik A.

AU - Anlauf, Martin

AU - Mottaghy, Felix M.

AU - Karges, Wolfram

PY - 2015/1

Y1 - 2015/1

N2 - A 51-year-old man with a history of metastatic medullary thyroid cancer (MTC) presented with high adrenocorticotropin (ACTH) and urinary free cortisol levels. The diagnosis of ectopic ACTH production, a rare MTC complication, was established in this patient. PET/CT using the somatostatin analogue DOTA-(Tyr)-octreotate labeled with gallium (Ga-DOTATATE) was performed, showing positive radionuclide uptake in multiple MTC metastases. After this therapy with the novel somatostatin analogue, pasireotide was initiated after which urinary free cortisol and ACTH levels decreased. The present case thus illustrates a potential theranostic use of Ga-DOTATATE PET/CT in MTC.

AB - A 51-year-old man with a history of metastatic medullary thyroid cancer (MTC) presented with high adrenocorticotropin (ACTH) and urinary free cortisol levels. The diagnosis of ectopic ACTH production, a rare MTC complication, was established in this patient. PET/CT using the somatostatin analogue DOTA-(Tyr)-octreotate labeled with gallium (Ga-DOTATATE) was performed, showing positive radionuclide uptake in multiple MTC metastases. After this therapy with the novel somatostatin analogue, pasireotide was initiated after which urinary free cortisol and ACTH levels decreased. The present case thus illustrates a potential theranostic use of Ga-DOTATATE PET/CT in MTC.

KW - somatostatin receptor

KW - Ga-68-DOTATATE

KW - PET/CT

KW - pasireotide

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M3 - Editorial

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SP - E83-E84

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

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