@article{3416958f63fc4de5a77409cbad3bf145,
title = "Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study",
abstract = "Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points center dot Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. center dot A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. center dot Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.",
keywords = "Breast neoplasms, Breast-conserving surgery, Magnetic resonance imaging, Mastectomy, Prospective studies, 20-YEAR FOLLOW-UP, SCREENING MAMMOGRAPHY, ADDITIONAL FINDINGS, CONSERVING SURGERY, MUTATION CARRIERS, CANCER, RESONANCE, RECOMMENDATIONS, WOMEN, METAANALYSIS",
author = "Francesco Sardanelli and Trimboli, {Rubina M.} and Nehmat Houssami and Gilbert, {Fiona J.} and Helbich, {Thomas H.} and {Alvarez Benito}, Marina and Corinne Balleyguier and Massimo Bazzocchi and Peter Bult and Massimo Calabrese and {Camps Herrero}, Julia and Francesco Cartia and Enrico Cassano and Paola Clauser and {de Andrade}, {Danubia A.} and {de Lima Docema}, {Marcos F.} and Catherine Depretto and Gabor Forrai and Rossano Girometti and Harms, {Steven E.} and Sarah Hilborne and Raffaele Ienzi and Lobbes, {Marc B. I.} and Claudio Losio and Mann, {Ritse M.} and Stefania Montemezzi and Inge-Marie Obdeijn and Ozcan, {Umit Aksoy} and Federica Pediconi and Heike Preibsch and Raya-Povedano, {Jose L.} and Daniela Sacchetto and Scaperrotta, {Gianfranco P.} and Margrethe Schlooz and Szabo, {Botond K.} and Ulus, {Ozden S.} and Taylor, {Donna B.} and {Van Goethem}, Mireille and Jeroen Veltman and Stefanie Weigel and Evelyn Wenkel and Chiara Zuiani and {Di Leo}, Giovanni",
note = "Funding Information: The study was promoted by the European Network for the Assessment of Imaging in Medicine (EuroAIM), initiative of the European Institute for Biomedical Imaging Research (EIBIR) and endorsed by the European Society of Breast Imaging. The authors thank Bayer Healthcare that provided an unconditional research grant, in particular Dr. Stephanie Schermuck-Joschko (who passed away for a car accident after the study started) and Dr. Jan Endrikat. The authors also thank Monika Hierath, Eva Haas, Katharina Krischak, and Peter Gordebeke from the EIBIR staff which managed all the administrative work of this study. The following persons collaborated at individual centers: Lucia Camera, MD, Department of Radiology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy; Sara Mirandola, MD, Department of Surgery, Azienda Ospedaliera Universitaria Integrata, Verona, Italy; Marta Maria Panzeri, MD, Department of Breast Radiology, IRCCS Ospedale San Raffaele, Milan, Italy; Maria A. Rodi Carvalho Barros Bernardes, MD and Vera L. Nunes Aguillar, MD, PhD, Department of Radiology, Hospital Sirio Libanes, Sao Paulo, Brazil; Katja Siegmann-Luz, MD and Benjamin Wiesinger, MD, Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Germany; James M. Anderson, Max Hobbs, and Wanda Gunawan, Royal Perth Hospital, Perth, Australia. Funding Information: Thomas Helbich receives research funding from Siemens, Guerbet, Bracco, Hologic and Nocomed. Funding Information: Fiona J Gilbert received research grants from GE Healthcare, GSK, and Hologic and had research collaborations with Volpara and Bayer. She is an NIHR senior investigator and receives funding from the Cambridge BRC. Publisher Copyright: {\textcopyright} 2020, European Society of Radiology.",
year = "2020",
month = oct,
doi = "10.1007/s00330-020-06824-7",
language = "English",
volume = "30",
pages = "5427--5436",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer, Cham",
number = "10",
}