Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release.

A.C.T.M. Vossen, G.J.M. Tibbe, W.A. Buurman, R. Benner, H.F.J. Savelkoul

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release.

Vossen AC, Tibbe GJ, Buurman WA, Benner R, Savelkoul HF.

Department of Immunology, Erasmus University, Rotterdam, The Netherlands.

The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
Original languageEnglish
Pages (from-to)751-755
JournalEuropean Cytokine Network
Volume7
Publication statusPublished - 1 Jan 1996

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