Abstract
Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release.
Vossen AC, Tibbe GJ, Buurman WA, Benner R, Savelkoul HF.
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
Vossen AC, Tibbe GJ, Buurman WA, Benner R, Savelkoul HF.
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
| Original language | English |
|---|---|
| Pages (from-to) | 751-755 |
| Journal | European Cytokine Network |
| Volume | 7 |
| Publication status | Published - 1 Jan 1996 |