Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release

A.C.T.M. Vossen, G.J.M. Tibbe, W.A. Buurman, R. Benner, H.F.J. Savelkoul

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2 Citations (Web of Science)


The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
Original languageEnglish
Pages (from-to)751-755
JournalEuropean Cytokine Network
Issue number4
Publication statusPublished - 1 Jan 1996

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