Soluble CD146-an underreported novel biomarker of congestion: a comment on a review concerning congestion assessment and evaluation in acute heart failure

J. Simonavicius*, A. Mikalauskas, H.P. Brunner-La Rocca

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

In spite of high prevalence, congestion remains a poorly understood phenomenon in heart failure pathophysiology. Its negative impact on outcome has been widely recognised. Still, data from various registries reveal the failure of the contemporary treatment strategies to overcome congestion. This shortcoming is closely related to the fact that there are no universe means for congestion assessment and grading, making it a difficult process to recognise. CD146 is a novel blood biomarker of congestion that has been shown to reflect intravascular fluid accumulation in a number of experimental and clinical studies. This observation deserves special attention, given the huge gap of knowledge about decongestive strategies in acute and chronic heart failure. Randomised clinical trials testing the effect of CD146-guided management intervention are urgently needed to estimate its value in heart failure care.
Original languageEnglish
Pages (from-to)731-732
Number of pages2
JournalHeart Failure Reviews
Volume26
Issue number3
Early online date6 May 2020
DOIs
Publication statusPublished - May 2021

Keywords

  • cd146
  • congestion
  • fluid accumulation
  • heart failure
  • loop diuretic
  • overhydration
  • Heart failure
  • Fluid accumulation
  • Loop diuretic
  • Overhydration
  • Congestion
  • CD146

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