Sodium intake and blood pressure in renal transplant recipients.

E. van den Berg, J.M. Geleijnse, E.J. Brink, M.A. van Baak, J.J. van der Heide, R.O. Gans, G. Navis, S.J. Bakker

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Abstract

BACKGROUND: Hypertension is common among renal transplant recipients (RTR) and a risk factor for graft failure and mortality. Sodium intake is a well-established determinant of blood pressure (BP) in the general population. However, data in RTR are limited. International guidelines recommend a maximum daily sodium intake of 70 mmol. We investigated sodium intake in RTR as compared to healthy controls and its association with BP.METHODS: We included 660 RTR (age 53 +/- 13 years, 58% male) and 201 healthy controls (age 54 +/- 11 years, 46% male). Sodium intake was assessed from 24-h urine collections. The morning after completion of urine collection, BP was measured according to a strict protocol.RESULTS: Urinary sodium excretion was 156 +/- 62 mmol/24 h in RTR and 195 +/- 75 in controls (difference: P < 0.001), and 95% of RTR had a urinary sodium excretion >70 mmol/24 h. Systolic BP (SBP) and diastolic BP (DBP) were 136 +/- 18 and 82 +/- 11 mmHg, respectively. Sodium intake was positively associated with SBP (beta = 0.042 mmHg/mmol/24 h, P = 0.002) and DBP (beta = 0.023 mmHg/mmol/24 h, P = 0.007), independent of potential confounders.CONCLUSIONS: Although RTR had a lower sodium intake than healthy controls, their intake still exceeded current guidelines. Reduction of sodium intake to recommended amounts could reduce SBP by 4-5 mmHg. Better control of sodium intake may help to prevent graft failure and mortality due to hypertension among RTR.
Original languageEnglish
Pages (from-to)3352-3359
JournalNephrology Dialysis Transplantation
Volume27
Issue number8
DOIs
Publication statusPublished - 1 Jan 2012

Cite this

van den Berg, E., Geleijnse, J. M., Brink, E. J., van Baak, M. A., van der Heide, J. J., Gans, R. O., Navis, G., & Bakker, S. J. (2012). Sodium intake and blood pressure in renal transplant recipients. Nephrology Dialysis Transplantation, 27(8), 3352-3359. https://doi.org/10.1093/ndt/gfs069