Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use

Stephen G. Waxman*, Ingemar S. J. Merkies, Monique M. Gerrits, Sulayman D. Dib-Hajj, Giuseppe Lauria, James J. Cox, John N. Wood, C. Geoffrey Woods, Joost P. H. Drenth, Catharina G. Faber

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

120 Citations (Web of Science)


Human studies have firmly implicated voltage-gated sodium channels in human pain disorders, and targeted and massively parallel genomic sequencing is beginning to be used in clinical practice to determine which sodium channel variants are involved. Missense substitutions of SCN9A, the gene encoding sodium channel Na(v)1.7, SCN10A, the gene encoding sodium channel Na(v)1.8, and SCN11A, the gene encoding sodium channel Na(v)1.9, produce gain-of-function changes that contribute to pain in many human painful disorders. Genomic sequencing might help to establish a diagnosis, and in the future might support individualisation of therapeutic approaches. However, in many cases, and especially in sodium channelopathies, the results from genomic sequencing can only be appropriately interpreted in the context of an extensive functional assessment, or family segregation analysis of phenotype and genotype.
Original languageEnglish
Pages (from-to)1152-1160
JournalLancet Neurology
Issue number11
Publication statusPublished - Nov 2014

Cite this