Sodium bicarbonate prophylactic therapy in the prevention of contrast-induced nephropathy in patients admitted to the intensive care unit of a teaching hospital: a retrospective cohort study

Nicole Lefel, Loes Janssen, Jos le Noble, Norbert A. Foudraine*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Intravenously administered iodine-containing contrast medium (CM) is associated with the development of contrast-induced nephropathy (CIN). Data on the effectiveness of sodium bicarbonate therapy in the prevention of CIN are controversial. Furthermore, the incidence of and risk factors for CIN in intensive care unit (ICU) patients are poorly defined. We investigated the effectiveness of sodium bicarbonate prophylaxis and the incidence of and risk factors for CIN in a heterogeneous ICU population.This retrospective cohort study included patients admitted to the ICU in 2009-2011 who received CM for computed tomography (CT).Two hundred eleven CT scans with CM, performed in 170 patients, were included in the study. Contrast prophylaxis with sodium bicarbonate was administered in 48 of the 211 cases. CIN developed in 19 of the 48 cases receiving prophylaxis and in 39 of 163 cases not receiving prophylaxis (p?=?0.03). In 115 CTs performed in patients with a glomerular filtration rate (GFR) >60?mL/min, prophylaxis was administered 15 times (13?%) and no prophylaxis was administered 100 times (87?%). CIN developed in 12 and 13?% of these cases, respectively (NS). In 96 CTs in patients with a GFR
Original languageEnglish
Article number5
JournalJournal of Intensive Care
Publication statusPublished - 12 Jan 2016


  • Contrast-induced nephropathy
  • Contrast-induced AKI
  • Prophylactic therapy
  • ICU

Cite this