Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts

Parisa Montazeri; Cathrine Thomsen; Maribel Casas; Jeroen de Bont; Line S. Haug; Lea Maitre; Eleni Papadopoulou; Amrit K. Sakhi; Remy Slama; Pierre Jean Saulnier; Jose Urquiza; Regina Grazulevicien; Sandra Andrusaityte; Rosie McEachan; John Wright; Leda Chatzi; Xavier Basagana; Martine Vrijheid

doi:10.1016/j.ijheh.2019.04.002

Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts

Parisa Montazeri, Cathrine Thomsen, Maribel Casas, Jeroen de Bont, Line S. Haug, Lea Maitre, Eleni Papadopoulou, Amrit K. Sakhi, Remy Slama, Pierre Jean Saulnier, Jose Urquiza, Regina Grazulevicien, Sandra Andrusaityte, Rosie McEachan, John Wright, Leda Chatzi, Xavier Basagana, Martine Vrijheid^*

^*Corresponding author for this work

NUTRIM - Respiratory & Age-related Health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants.

Methods: Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers of exposure to 41 contaminants in biological samples from children (6-12 years) and their mothers during pregnancy, including organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), metals, phthalate metabolites, phenols, and organophosphate (OP) pesticide metabolites. We analyzed these biomarkers with several socioeconomic position (SEP) indicators (maternal education, employment status and family affluence scale).

Results: Higher SEP was associated with higher concentrations of several chemicals during pregnancy, including certain PFASs, mercury, arsenic, several phenols, and OP pesticides. Similarly, childhood concentrations of OCs, PFASs, mercury, arsenic, and bisphenol A were higher in higher SEP groups. Conversely, cadmium exposure during pregnancy and exposure to lead and phthalate metabolites in childhood were higher in lower SEP. Principal components representing multiple pollutant exposures showed similar association with SEP.

Conclusions: This study demonstrates that environmental chemical contaminant exposure during fetal and childhood life is not exclusively associated to lower SEP and that for several contaminants higher SEP groups incur higher exposure levels.

Original language	English
Pages (from-to)	864-872
Number of pages	9
Journal	International Journal of Hygiene and Environmental Health
Volume	222
Issue number	5
DOIs	https://doi.org/10.1016/j.ijheh.2019.04.002
Publication status	Published - Jun 2019

Keywords

BISPHENOL-A
CHAINED EQUATIONS
DETERMINANTS
HEALTH
MERCURY LEVELS
NORWEGIAN MOTHER
PERFLUOROALKYL SUBSTANCES
PREGNANT-WOMEN
URINARY CONCENTRATIONS
US CHILDREN
DISPARITIES

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10.1016/j.ijheh.2019.04.002

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Montazeri, P., Thomsen, C., Casas, M., de Bont, J., Haug, L. S., Maitre, L., Papadopoulou, E., Sakhi, A. K., Slama, R., Saulnier, P. J., Urquiza, J., Grazulevicien, R., Andrusaityte, S., McEachan, R., Wright, J., Chatzi, L., Basagana, X., & Vrijheid, M. (2019). Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts. International Journal of Hygiene and Environmental Health, 222(5), 864-872. https://doi.org/10.1016/j.ijheh.2019.04.002

@article{4793e715fba5445daace008c5d2fa259,

title = "Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts",

abstract = "Background: Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants.Methods: Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers of exposure to 41 contaminants in biological samples from children (6-12 years) and their mothers during pregnancy, including organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), metals, phthalate metabolites, phenols, and organophosphate (OP) pesticide metabolites. We analyzed these biomarkers with several socioeconomic position (SEP) indicators (maternal education, employment status and family affluence scale).Results: Higher SEP was associated with higher concentrations of several chemicals during pregnancy, including certain PFASs, mercury, arsenic, several phenols, and OP pesticides. Similarly, childhood concentrations of OCs, PFASs, mercury, arsenic, and bisphenol A were higher in higher SEP groups. Conversely, cadmium exposure during pregnancy and exposure to lead and phthalate metabolites in childhood were higher in lower SEP. Principal components representing multiple pollutant exposures showed similar association with SEP.Conclusions: This study demonstrates that environmental chemical contaminant exposure during fetal and childhood life is not exclusively associated to lower SEP and that for several contaminants higher SEP groups incur higher exposure levels.",

keywords = "BISPHENOL-A, CHAINED EQUATIONS, DETERMINANTS, HEALTH, MERCURY LEVELS, NORWEGIAN MOTHER, PERFLUOROALKYL SUBSTANCES, PREGNANT-WOMEN, URINARY CONCENTRATIONS, US CHILDREN, DISPARITIES",

author = "Parisa Montazeri and Cathrine Thomsen and Maribel Casas and {de Bont}, Jeroen and Haug, {Line S.} and Lea Maitre and Eleni Papadopoulou and Sakhi, {Amrit K.} and Remy Slama and Saulnier, {Pierre Jean} and Jose Urquiza and Regina Grazulevicien and Sandra Andrusaityte and Rosie McEachan and John Wright and Leda Chatzi and Xavier Basagana and Martine Vrijheid",

note = "Funding Information: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007?2013) under grant agreement no 308333 ? the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER-funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundaci? La marat? de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds). We are grateful to all the participating children, parents, practitioners and researchers in the six cohorts who took part in this study, especially to those families in addition donated blood and urine to this specific HELIX study. More details can be found in Supplementary Material S21. Funding Information: The research leading to these results has received funding from the European Community{\textquoteright}s Seventh Framework Programme ( FP7/2007–2013 ) under grant agreement no 308333 – the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III ( Ministry of Economy and Competitiveness ) ( MS16/00128 ). The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III ( Red INMA G03/176 ; CB06/02/0041 ; PI041436 ; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER-funds), CIBERESP , Generalitat de Catalunya- CIRIT 1999SGR 00241 , Generalitat de Catalunya-AGAUR ( 2009 SGR 501 , 2014 SGR 822 ), Fundaci{\'o} La marat{\'o} de TV3 ( 090430 ), Spanish Ministry of Economy and Competitiveness ( SAF2012-32991 incl. FEDER funds). Publisher Copyright: {\textcopyright} 2019 Elsevier GmbH",

year = "2019",

month = jun,

doi = "10.1016/j.ijheh.2019.04.002",

language = "English",

volume = "222",

pages = "864--872",

journal = "International Journal of Hygiene and Environmental Health",

issn = "1438-4639",

publisher = "Elsevier GmbH",

number = "5",

}

Montazeri, P, Thomsen, C, Casas, M, de Bont, J, Haug, LS, Maitre, L, Papadopoulou, E, Sakhi, AK, Slama, R, Saulnier, PJ, Urquiza, J, Grazulevicien, R, Andrusaityte, S, McEachan, R, Wright, J, Chatzi, L, Basagana, X & Vrijheid, M 2019, 'Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts', International Journal of Hygiene and Environmental Health, vol. 222, no. 5, pp. 864-872. https://doi.org/10.1016/j.ijheh.2019.04.002

TY - JOUR

T1 - Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts

AU - Montazeri, Parisa

AU - Thomsen, Cathrine

AU - Casas, Maribel

AU - de Bont, Jeroen

AU - Haug, Line S.

AU - Maitre, Lea

AU - Papadopoulou, Eleni

AU - Sakhi, Amrit K.

AU - Slama, Remy

AU - Saulnier, Pierre Jean

AU - Urquiza, Jose

AU - Grazulevicien, Regina

AU - Andrusaityte, Sandra

AU - McEachan, Rosie

AU - Wright, John

AU - Chatzi, Leda

AU - Basagana, Xavier

AU - Vrijheid, Martine

N1 - Funding Information: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007?2013) under grant agreement no 308333 ? the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER-funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundaci? La marat? de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds). We are grateful to all the participating children, parents, practitioners and researchers in the six cohorts who took part in this study, especially to those families in addition donated blood and urine to this specific HELIX study. More details can be found in Supplementary Material S21. Funding Information: The research leading to these results has received funding from the European Community’s Seventh Framework Programme ( FP7/2007–2013 ) under grant agreement no 308333 – the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III ( Ministry of Economy and Competitiveness ) ( MS16/00128 ). The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III ( Red INMA G03/176 ; CB06/02/0041 ; PI041436 ; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER-funds), CIBERESP , Generalitat de Catalunya- CIRIT 1999SGR 00241 , Generalitat de Catalunya-AGAUR ( 2009 SGR 501 , 2014 SGR 822 ), Fundació La marató de TV3 ( 090430 ), Spanish Ministry of Economy and Competitiveness ( SAF2012-32991 incl. FEDER funds). Publisher Copyright: © 2019 Elsevier GmbH

PY - 2019/6

Y1 - 2019/6

N2 - Background: Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants.Methods: Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers of exposure to 41 contaminants in biological samples from children (6-12 years) and their mothers during pregnancy, including organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), metals, phthalate metabolites, phenols, and organophosphate (OP) pesticide metabolites. We analyzed these biomarkers with several socioeconomic position (SEP) indicators (maternal education, employment status and family affluence scale).Results: Higher SEP was associated with higher concentrations of several chemicals during pregnancy, including certain PFASs, mercury, arsenic, several phenols, and OP pesticides. Similarly, childhood concentrations of OCs, PFASs, mercury, arsenic, and bisphenol A were higher in higher SEP groups. Conversely, cadmium exposure during pregnancy and exposure to lead and phthalate metabolites in childhood were higher in lower SEP. Principal components representing multiple pollutant exposures showed similar association with SEP.Conclusions: This study demonstrates that environmental chemical contaminant exposure during fetal and childhood life is not exclusively associated to lower SEP and that for several contaminants higher SEP groups incur higher exposure levels.

AB - Background: Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants.Methods: Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers of exposure to 41 contaminants in biological samples from children (6-12 years) and their mothers during pregnancy, including organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), metals, phthalate metabolites, phenols, and organophosphate (OP) pesticide metabolites. We analyzed these biomarkers with several socioeconomic position (SEP) indicators (maternal education, employment status and family affluence scale).Results: Higher SEP was associated with higher concentrations of several chemicals during pregnancy, including certain PFASs, mercury, arsenic, several phenols, and OP pesticides. Similarly, childhood concentrations of OCs, PFASs, mercury, arsenic, and bisphenol A were higher in higher SEP groups. Conversely, cadmium exposure during pregnancy and exposure to lead and phthalate metabolites in childhood were higher in lower SEP. Principal components representing multiple pollutant exposures showed similar association with SEP.Conclusions: This study demonstrates that environmental chemical contaminant exposure during fetal and childhood life is not exclusively associated to lower SEP and that for several contaminants higher SEP groups incur higher exposure levels.

KW - BISPHENOL-A

KW - CHAINED EQUATIONS

KW - DETERMINANTS

KW - HEALTH

KW - MERCURY LEVELS

KW - NORWEGIAN MOTHER

KW - PERFLUOROALKYL SUBSTANCES

KW - PREGNANT-WOMEN

KW - URINARY CONCENTRATIONS

KW - US CHILDREN

KW - DISPARITIES

U2 - 10.1016/j.ijheh.2019.04.002

DO - 10.1016/j.ijheh.2019.04.002

M3 - Article

C2 - 31010791

SN - 1438-4639

VL - 222

SP - 864

EP - 872

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

IS - 5

ER -

Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts

Abstract

Keywords

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