TY - JOUR
T1 - Sociodemographic, Clinical, Lifestyle, and Psychological Correlates of Peripheral Neuropathy among 2- to 12-Year Colorectal Cancer Survivors
AU - Révész, Dóra
AU - Bonhof, Cynthia S
AU - Bours, Martijn J L
AU - Weijenberg, Matty P
AU - Vreugdenhil, Gerard
AU - van de Poll-Franse, Lonneke V
AU - Mols, Floortje
N1 - © 2022 The Author(s). Published by S. Karger AG, Basel.
PY - 2022/8
Y1 - 2022/8
N2 - BACKGROUND: Peripheral neuropathy (PN) is a debilitating complication among colorectal cancer (CRC) survivors that can become chronic. No large-scale study has yet analyzed correlates in multivariable models. We did multivariable analyses to find correlates of PN.METHODS: In 1,516 all-stage Dutch CRC survivors, cross-sectional data were collected on sensory, motor, autonomic, and total PN, sociodemographic (age, sex, education, employment, partner), clinical (time since diagnosis, tumor location, stage, chemotherapy, radiotherapy, comorbidities), lifestyle (alcohol, smoking, physical activity, body mass index), psychological factors (anxiety, depression, personality), and health-related quality of life (HRQoL). After multiple imputations, correlates were analyzed with linear regressions and eliminated with backward selection.RESULTS: CRC survivors (69 years; 42% female) were on average 5 years post-diagnosis, and 28%-65% reported PN. PN was associated with older age, being male (sensory) or female (motor), shorter time since diagnosis, chemotherapy, comorbidities, anxiety, depression, and worse scores on HRQoL domains, and pain, nausea, vomiting, insomnia, constipation, and financial problems.CONCLUSIONS: In multivariable analyses, PN is affected by receiving chemotherapy, aging, sex, comorbidities, stress-related factors, and HRQoL in CRC survivors. Future PN-related studies can include these factors, and they can be examined in longitudinal studies to gain more knowledge about chronicity and severity of PN.
AB - BACKGROUND: Peripheral neuropathy (PN) is a debilitating complication among colorectal cancer (CRC) survivors that can become chronic. No large-scale study has yet analyzed correlates in multivariable models. We did multivariable analyses to find correlates of PN.METHODS: In 1,516 all-stage Dutch CRC survivors, cross-sectional data were collected on sensory, motor, autonomic, and total PN, sociodemographic (age, sex, education, employment, partner), clinical (time since diagnosis, tumor location, stage, chemotherapy, radiotherapy, comorbidities), lifestyle (alcohol, smoking, physical activity, body mass index), psychological factors (anxiety, depression, personality), and health-related quality of life (HRQoL). After multiple imputations, correlates were analyzed with linear regressions and eliminated with backward selection.RESULTS: CRC survivors (69 years; 42% female) were on average 5 years post-diagnosis, and 28%-65% reported PN. PN was associated with older age, being male (sensory) or female (motor), shorter time since diagnosis, chemotherapy, comorbidities, anxiety, depression, and worse scores on HRQoL domains, and pain, nausea, vomiting, insomnia, constipation, and financial problems.CONCLUSIONS: In multivariable analyses, PN is affected by receiving chemotherapy, aging, sex, comorbidities, stress-related factors, and HRQoL in CRC survivors. Future PN-related studies can include these factors, and they can be examined in longitudinal studies to gain more knowledge about chronicity and severity of PN.
KW - Cancer survivors
KW - Colorectal cancer
KW - Peripheral neuropathy
KW - Psychological stress
KW - Quality of life
U2 - 10.1159/000524037
DO - 10.1159/000524037
M3 - Article
C2 - 35306496
SN - 2296-5270
VL - 45
SP - 480
EP - 493
JO - Oncology Research and Treatment
JF - Oncology Research and Treatment
IS - 9
ER -