Smoking status in relation to serum folate and dietary vitamin intake

C.I. Vardavas, M.K. Linardakis, C.M. Hatzis, N. Malliaraki, W.H. Saris, A.G. Kafatos

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Abstract

Objective
Cigarette smoke itself is an abundant source of free radicals and a major cause of oxidative stress, to which plasma antioxidants function as a vital protective and counterbalancing mechanism. The objective of this study was to investigate into the relationship between smoking status and serum and dietary micronutrient concentrations.


Design
Cross-sectional study


Subjects ' Setting
502 farmers from the Valley of Messara in Crete were randomly selected and examined. Complete three-day and 24-hr recall questionnaires were collected along with anthropometrical, physical activity and clinical data from all participating subjects.


Results
After adjusting for age, gender and number of fasting days adhered to per year, current smokers were found to have a lower dietary intake of vitamin C (112.1 mg vs. 136.4 mg, p = 0.03), fibre (16.6 g vs. 19.1 g, p = 0.006) and fruits and vegetables (339 g vs. 412 g, p = 0.014), while dietary vitamin B1 intake was found to be higher (1.7 mg vs. 1.4 mg, p = 0.02) in comparison to non/ex smokers. Dietary intake of meat, folate and vitami A, E, B2, B6 and B12 did not differ between the groups. Controlling age, gender, fasting days and dietary micronutrient intake, serum folate levels were found to be lower among smokers (geometric mean 15.3 nmol/L vs. 17.7 nmol/L, p = 0.023), while serum iron and vitamin B12 levels were not affected by smoking status.


Conclusion
Current smoking status affects dietary nutrient intake as well as plasma folate levels. The above coherence between antioxidant depletion and reduced antioxidant intake may predispose smokers to the premature development of tobacco related mortality and morbidity.
Original languageEnglish
Pages (from-to)8
JournalTobacco Induced Diseases
Volume4
Issue number1
DOIs
Publication statusPublished - 1 Jan 2008

Cite this

Vardavas, C. I., Linardakis, M. K., Hatzis, C. M., Malliaraki, N., Saris, W. H., & Kafatos, A. G. (2008). Smoking status in relation to serum folate and dietary vitamin intake. Tobacco Induced Diseases, 4(1), 8. https://doi.org/10.1186/1617-9625-4-8