Smart biomaterials: From responsiveness to closed-loop sensing and feedback

Masoud Mozafari; Tatjana Ivaskiene; Greta Kaspute; Ali Mobasheri

doi:10.1016/j.tibtech.2026.06.016

Smart biomaterials: From responsiveness to closed-loop sensing and feedback

Masoud Mozafari^*
, Tatjana Ivaskiene
, Greta Kaspute
, Ali Mobasheri

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

Biomaterials are evolving from passive scaffolds to responsive platforms, yet most lack true feedback regulation. A shift toward adaptive biomaterial systems that integrate sensing, computational processing, and dynamic actuation directly within a macromolecular network could transform these multifunctional biomaterials into precision platforms capable of regulating biological processes in real time.

Original language	English
Number of pages	5
Journal	Trends in Biotechnology
DOIs	https://doi.org/10.1016/j.tibtech.2026.06.016
Publication status	E-pub ahead of print - Jul 2026

Keywords

biointerfaces
biomaterials
closed-loop systems
feedback control
precision therapy

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10.1016/j.tibtech.2026.06.016Licence: CC BY

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@article{adbb782ddd4748e485f54fdd9879b4b0,

title = "Smart biomaterials: From responsiveness to closed-loop sensing and feedback",

abstract = "Biomaterials are evolving from passive scaffolds to responsive platforms, yet most lack true feedback regulation. A shift toward adaptive biomaterial systems that integrate sensing, computational processing, and dynamic actuation directly within a macromolecular network could transform these multifunctional biomaterials into precision platforms capable of regulating biological processes in real time.",

keywords = "biointerfaces, biomaterials, closed-loop systems, feedback control, precision therapy",

author = "Masoud Mozafari and Tatjana Ivaskiene and Greta Kaspute and Ali Mobasheri",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors",

year = "2026",

month = jul,

doi = "10.1016/j.tibtech.2026.06.016",

language = "English",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Smart biomaterials

T2 - From responsiveness to closed-loop sensing and feedback

AU - Mozafari, Masoud

AU - Ivaskiene, Tatjana

AU - Kaspute, Greta

AU - Mobasheri, Ali

PY - 2026/7

Y1 - 2026/7

N2 - Biomaterials are evolving from passive scaffolds to responsive platforms, yet most lack true feedback regulation. A shift toward adaptive biomaterial systems that integrate sensing, computational processing, and dynamic actuation directly within a macromolecular network could transform these multifunctional biomaterials into precision platforms capable of regulating biological processes in real time.

AB - Biomaterials are evolving from passive scaffolds to responsive platforms, yet most lack true feedback regulation. A shift toward adaptive biomaterial systems that integrate sensing, computational processing, and dynamic actuation directly within a macromolecular network could transform these multifunctional biomaterials into precision platforms capable of regulating biological processes in real time.

KW - biointerfaces

KW - biomaterials

KW - closed-loop systems

KW - feedback control

KW - precision therapy

U2 - 10.1016/j.tibtech.2026.06.016

DO - 10.1016/j.tibtech.2026.06.016

M3 - Short survey

SN - 0167-7799

JO - Trends in Biotechnology

JF - Trends in Biotechnology

ER -

Smart biomaterials: From responsiveness to closed-loop sensing and feedback

Abstract

Keywords

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