SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY

Mayienne Bakkers*, Catharina G. Faber, Janneke G. J. Hoeijmakers, Giuseppe Lauria, Ingemar S. J. Merkies

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings. Muscle Nerve49:329-336, 2014
Original languageEnglish
Pages (from-to)329-336
JournalMuscle & Nerve
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • clinimetric evaluation
  • pain
  • polyneuropathy
  • quality of life
  • small-fiber neuropathy

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