SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY

Mayienne Bakkers; Catharina G. Faber; Janneke G. J. Hoeijmakers; Giuseppe Lauria; Ingemar S. J. Merkies

doi:10.1002/mus.23910

SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY

Mayienne Bakkers^*, Catharina G. Faber, Janneke G. J. Hoeijmakers, Giuseppe Lauria, Ingemar S. J. Merkies

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings. Muscle Nerve49:329-336, 2014

Original language	English
Pages (from-to)	329-336
Journal	Muscle & Nerve
Volume	49
Issue number	3
DOIs	https://doi.org/10.1002/mus.23910
Publication status	Published - Mar 2014

Keywords

clinimetric evaluation
pain
polyneuropathy
quality of life
small-fiber neuropathy

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10.1002/mus.23910

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title = "SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY",

abstract = "Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings. Muscle Nerve49:329-336, 2014",

keywords = "clinimetric evaluation, pain, polyneuropathy, quality of life, small-fiber neuropathy",

author = "Mayienne Bakkers and Faber, {Catharina G.} and Hoeijmakers, {Janneke G. J.} and Giuseppe Lauria and Merkies, {Ingemar S. J.}",

year = "2014",

month = mar,

doi = "10.1002/mus.23910",

language = "English",

volume = "49",

pages = "329--336",

journal = "Muscle & Nerve",

issn = "0148-639X",

publisher = "Wiley",

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T1 - SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY

AU - Bakkers, Mayienne

AU - Faber, Catharina G.

AU - Hoeijmakers, Janneke G. J.

AU - Lauria, Giuseppe

AU - Merkies, Ingemar S. J.

PY - 2014/3

Y1 - 2014/3

N2 - Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings. Muscle Nerve49:329-336, 2014

AB - Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings. Muscle Nerve49:329-336, 2014

KW - clinimetric evaluation

KW - pain

KW - polyneuropathy

KW - quality of life

KW - small-fiber neuropathy

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DO - 10.1002/mus.23910

M3 - Article

C2 - 23716362

SN - 0148-639X

VL - 49

SP - 329

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JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 3

ER -

SMALL FIBERS, LARGE IMPACT: QUALITY OF LIFE IN SMALL-FIBER NEUROPATHY

Abstract

Keywords

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