Sleep efficiency as a determinant of insulin sensitivity in overweight and obese adolescents

E. Dorenbos, J.M. Rijks, T.C. Adam, M.S. Westerterp-Plantenga, A.C. Vreugdenhil

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Insulin resistance (IR) occurs in a transient manner during puberty. Obese adolescents may be at risk for persistent IR during puberty. The objective of the study is to review the literature on the association of the anthropometry and lifestyle characteristics with insulin sensitivity in overweight and obese adolescents, and include data from a new study. Relevant papers were selected and reviewed. In addition, 137 overweight and obese adolescents (42 male/95 female, age 14.4 +/- 2.3 years, BMI z-score +3.3 +/- 0.7, HOMA-IR 3.4 +/- 1.8) from the Centre for Overweight Adolescent and Children's Healthcare (MUMC+) were included in this study. Anthropometrics, Tanner stages, sleep characteristics, food intake behaviour and physical activity were determined, and possible associations with homeostasis model assessment of insulin resistance (HOMA-IR) were tested. RESULTS: Overweight and obese adolescents with unfavourable fat partitioning and family history of NIDDM are at risk for persistent IR. Overweight and obese adolescents from the new cohort showed a higher HOMA-IR postpubertally. BMI z-score, age, pubertal stage and prepubertally total sleeping time (TST) and sleep efficiency (SE) were identified as significant contributors. Overweight and obese adolescents showed a persistently higher instead of transiently higher HOMA-IR during puberty, associated with BMI z-score, age, pubertal stage and prepubertally less TST and SE.
Original languageEnglish
Pages (from-to)90-98
Number of pages9
JournalDiabetes Obesity & Metabolism
Volume17
DOIs
Publication statusPublished - Sep 2015

Keywords

  • food intake behaviour
  • physical activity
  • pubertal persistent insulin resistance
  • pubertal transient insulin resistance
  • sleep
  • HOMEOSTASIS MODEL ASSESSMENT
  • DUTCH CHILDREN COHORT
  • BETA-CELL FUNCTION
  • BODY-MASS INDEX
  • PHYSICAL-ACTIVITY
  • ENERGY-BALANCE
  • PUBERTAL CHANGES
  • RISK-FACTORS
  • FOOD CHOICE
  • LIFE-STYLE

Cite this

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title = "Sleep efficiency as a determinant of insulin sensitivity in overweight and obese adolescents",
abstract = "Insulin resistance (IR) occurs in a transient manner during puberty. Obese adolescents may be at risk for persistent IR during puberty. The objective of the study is to review the literature on the association of the anthropometry and lifestyle characteristics with insulin sensitivity in overweight and obese adolescents, and include data from a new study. Relevant papers were selected and reviewed. In addition, 137 overweight and obese adolescents (42 male/95 female, age 14.4 +/- 2.3 years, BMI z-score +3.3 +/- 0.7, HOMA-IR 3.4 +/- 1.8) from the Centre for Overweight Adolescent and Children's Healthcare (MUMC+) were included in this study. Anthropometrics, Tanner stages, sleep characteristics, food intake behaviour and physical activity were determined, and possible associations with homeostasis model assessment of insulin resistance (HOMA-IR) were tested. RESULTS: Overweight and obese adolescents with unfavourable fat partitioning and family history of NIDDM are at risk for persistent IR. Overweight and obese adolescents from the new cohort showed a higher HOMA-IR postpubertally. BMI z-score, age, pubertal stage and prepubertally total sleeping time (TST) and sleep efficiency (SE) were identified as significant contributors. Overweight and obese adolescents showed a persistently higher instead of transiently higher HOMA-IR during puberty, associated with BMI z-score, age, pubertal stage and prepubertally less TST and SE.",
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author = "E. Dorenbos and J.M. Rijks and T.C. Adam and M.S. Westerterp-Plantenga and A.C. Vreugdenhil",
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Sleep efficiency as a determinant of insulin sensitivity in overweight and obese adolescents. / Dorenbos, E.; Rijks, J.M.; Adam, T.C.; Westerterp-Plantenga, M.S.; Vreugdenhil, A.C.

In: Diabetes Obesity & Metabolism, Vol. 17, 09.2015, p. 90-98.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Sleep efficiency as a determinant of insulin sensitivity in overweight and obese adolescents

AU - Dorenbos, E.

AU - Rijks, J.M.

AU - Adam, T.C.

AU - Westerterp-Plantenga, M.S.

AU - Vreugdenhil, A.C.

PY - 2015/9

Y1 - 2015/9

N2 - Insulin resistance (IR) occurs in a transient manner during puberty. Obese adolescents may be at risk for persistent IR during puberty. The objective of the study is to review the literature on the association of the anthropometry and lifestyle characteristics with insulin sensitivity in overweight and obese adolescents, and include data from a new study. Relevant papers were selected and reviewed. In addition, 137 overweight and obese adolescents (42 male/95 female, age 14.4 +/- 2.3 years, BMI z-score +3.3 +/- 0.7, HOMA-IR 3.4 +/- 1.8) from the Centre for Overweight Adolescent and Children's Healthcare (MUMC+) were included in this study. Anthropometrics, Tanner stages, sleep characteristics, food intake behaviour and physical activity were determined, and possible associations with homeostasis model assessment of insulin resistance (HOMA-IR) were tested. RESULTS: Overweight and obese adolescents with unfavourable fat partitioning and family history of NIDDM are at risk for persistent IR. Overweight and obese adolescents from the new cohort showed a higher HOMA-IR postpubertally. BMI z-score, age, pubertal stage and prepubertally total sleeping time (TST) and sleep efficiency (SE) were identified as significant contributors. Overweight and obese adolescents showed a persistently higher instead of transiently higher HOMA-IR during puberty, associated with BMI z-score, age, pubertal stage and prepubertally less TST and SE.

AB - Insulin resistance (IR) occurs in a transient manner during puberty. Obese adolescents may be at risk for persistent IR during puberty. The objective of the study is to review the literature on the association of the anthropometry and lifestyle characteristics with insulin sensitivity in overweight and obese adolescents, and include data from a new study. Relevant papers were selected and reviewed. In addition, 137 overweight and obese adolescents (42 male/95 female, age 14.4 +/- 2.3 years, BMI z-score +3.3 +/- 0.7, HOMA-IR 3.4 +/- 1.8) from the Centre for Overweight Adolescent and Children's Healthcare (MUMC+) were included in this study. Anthropometrics, Tanner stages, sleep characteristics, food intake behaviour and physical activity were determined, and possible associations with homeostasis model assessment of insulin resistance (HOMA-IR) were tested. RESULTS: Overweight and obese adolescents with unfavourable fat partitioning and family history of NIDDM are at risk for persistent IR. Overweight and obese adolescents from the new cohort showed a higher HOMA-IR postpubertally. BMI z-score, age, pubertal stage and prepubertally total sleeping time (TST) and sleep efficiency (SE) were identified as significant contributors. Overweight and obese adolescents showed a persistently higher instead of transiently higher HOMA-IR during puberty, associated with BMI z-score, age, pubertal stage and prepubertally less TST and SE.

KW - food intake behaviour

KW - physical activity

KW - pubertal persistent insulin resistance

KW - pubertal transient insulin resistance

KW - sleep

KW - HOMEOSTASIS MODEL ASSESSMENT

KW - DUTCH CHILDREN COHORT

KW - BETA-CELL FUNCTION

KW - BODY-MASS INDEX

KW - PHYSICAL-ACTIVITY

KW - ENERGY-BALANCE

KW - PUBERTAL CHANGES

KW - RISK-FACTORS

KW - FOOD CHOICE

KW - LIFE-STYLE

U2 - 10.1111/dom.12515

DO - 10.1111/dom.12515

M3 - Article

VL - 17

SP - 90

EP - 98

JO - Diabetes Obesity & Metabolism

JF - Diabetes Obesity & Metabolism

SN - 1462-8902

ER -