Sleep duration and incidence of obesity in infants, children, and adolescents: a systematic review and meta-analysis of prospective studies.

Michelle A. Miller, Marlot Kruisbrink, Joanne Wallace, Chen Ji, Francesco P Cappuccio

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Study Objectives: To assess the prospective relationship between sleep and obesity in a paediatric population.

Methods: We performed a systematic search using PubMed, Embase, Web of Science, and Cochrane (up to September 25, 2017). Included studies were prospective, had follow-up of >= 1 year, had duration of sleep at baseline, and measures of incidence of overweight or obesity and/or changes in body mass index (BMI) z-score and BMI during follow-up. We extracted relative risks or changes in BMI z-score or BMI and 95% confidence intervals (CI) and pooled them using a random effect model.

Results: Forty-two studies were included but, as there was significant heterogeneity, results are presented by age strata. Short sleep was associated with a greater risk of developing overweight or obesity in infancy (seven studies, 14 738 participants, risk ratio [RR]: 1.40; 95% CI 1.19 to 1.65; p <.001), early childhood (eight studies, 31 104 participants, RR: 1.57; 1.40 to 1.76; p <.001), middle childhood (three studies, 3 005 participants, RR: 2.23; 2.18 to 2.27; p <.001), and adolescence (three studies, 26 652 participants, RR: 1.30; 1.11 to 1.53; p <.002). Sleep duration was also associated with a significant change in BMI z-score (14 studies, 18 cohorts, 31 665 participants; mean difference -0.03; -0.04 to -0.01 per hour sleep; p = .001) and in BMI (16 studies, 24 cohorts, 24 894 participants; mean difference -0.03 kg/m(2); -0.04 to -0.01 for every hour of increase in sleep; p = .001)

Conclusions: Short sleep duration is a risk factor or marker of the development of obesity in infants, children, and adolescents.

Original languageEnglish
Article number018
Number of pages19
JournalSleep
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 2018
Externally publishedYes

Keywords

  • BODY-MASS INDEX
  • CHILDHOOD OVERWEIGHT
  • EARLY-LIFE
  • ELEVATED GHRELIN
  • FAT-FREE MASS
  • INSUFFICIENT SLEEP
  • LONGITUDINAL ASSOCIATIONS
  • PUBLICATION BIAS
  • RISK-FACTORS
  • WEIGHT-GAIN
  • adolescents
  • body mass index
  • infants
  • meta-analysis
  • obesity
  • overweight
  • prospective
  • sleep deprivation

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