Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.

P. Schrauwen, J. Xia, C. Bogardus, R.E. Pratley, E. Ravussin

Research output: Contribution to journalArticleAcademicpeer-review

109 Citations (Scopus)

Abstract

Department of Human Biology, Maastricht University, The Netherlands.

The recent discovery of uncoupling protein (UCP)-2 and UCP-3, and their high expression in skeletal muscle, has renewed interest in a possible role for these proteins in underlying the variability in energy expenditure and therefore metabolic efficiency. Using reverse transcription-polymerase chain reaction, levels of expression of UCP-2 and long and short forms of UCP-3 were measured in skeletal muscle of 19 nondiabetic, male Pima Indians covering a wide range of body weight. Twenty-four-hour energy expenditure was measured in a respiratory chamber in 16 of these individuals. BMI was negatively correlated with the expression levels of the long (r = -0.53, P = 0.025) and short (r = -0.46, P = 0.047) forms of UCP-3. BMI was not correlated with UCP-2 expression. Metabolic rate during sleep, adjusted for fat-free mass and fat mass, was positively correlated with the long form of UCP-3 (r = 0.69, P = 0.006). These results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians.
Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalDiabetes
Volume48
Issue number1
DOIs
Publication statusPublished - 1 Jan 1999

Cite this

Schrauwen, P. ; Xia, J. ; Bogardus, C. ; Pratley, R.E. ; Ravussin, E. / Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. In: Diabetes. 1999 ; Vol. 48, No. 1. pp. 146-149.
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Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. / Schrauwen, P.; Xia, J.; Bogardus, C.; Pratley, R.E.; Ravussin, E.

In: Diabetes, Vol. 48, No. 1, 01.01.1999, p. 146-149.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Xia, J.

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AB - Department of Human Biology, Maastricht University, The Netherlands.The recent discovery of uncoupling protein (UCP)-2 and UCP-3, and their high expression in skeletal muscle, has renewed interest in a possible role for these proteins in underlying the variability in energy expenditure and therefore metabolic efficiency. Using reverse transcription-polymerase chain reaction, levels of expression of UCP-2 and long and short forms of UCP-3 were measured in skeletal muscle of 19 nondiabetic, male Pima Indians covering a wide range of body weight. Twenty-four-hour energy expenditure was measured in a respiratory chamber in 16 of these individuals. BMI was negatively correlated with the expression levels of the long (r = -0.53, P = 0.025) and short (r = -0.46, P = 0.047) forms of UCP-3. BMI was not correlated with UCP-2 expression. Metabolic rate during sleep, adjusted for fat-free mass and fat mass, was positively correlated with the long form of UCP-3 (r = 0.69, P = 0.006). These results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians.

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