Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men.

L.B. Verdijk, B.G. Gleeson, R.A. Jonkers, K. Meijer, H.H. Savelberg, P. Dendale, L.J. van Loon

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    We determined muscle fiber type-specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 +/- 2 years). Leg strength and body composition (dual-energy X-ray absorptiometry and computed tomography) were assessed, and muscle biopsy samples were collected. Leg strength increased 25%-30% after training (p < .001). Leg lean mass and quadriceps cross-sectional area increased 6%-9% (p < .001). At baseline, mean fiber area and SC content were smaller in the Type II versus Type I muscle fibers (p < .01). Following training, Type II muscle fiber area increased from 5,438 +/- 319 to 6,982 +/- 503 mum(2) (p < .01). Type II muscle fiber SC content increased from 0.048 +/- 0.003 to 0.084 +/- 0.008 SCs per fiber (p < .001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy.
    Original languageEnglish
    Pages (from-to)332-339
    JournalJournals of Gerontology Series A-Biological Sciences and Medical Sciences
    Volume64
    Issue number3
    DOIs
    Publication statusPublished - 1 Jan 2009

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