Simultaneous acquisition of cerebral blood volume-, blood flow-, and blood oxygenation-weighted MRI signals at ultra-high magnetic field

Steffen N. Krieger*, Laurentius Huber, Benedikt A. Poser, Robert Turner, Gary F. Egan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)
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Purpose Yang et al. proposed an MRI technique for the simultaneous acquisition of cerebral blood volume (CBV), cerebral blood flow (CBF), and blood oxygenation level-dependent (BOLD)-weighted MRI signals (9). The purpose of this study was to develop modified version of the Yang sequence, which utilizes the advantages of 7 Tesla, leading to a robust and reliable MRI sequence. MethodsThe inversion recovery-based MR pulse sequence introduced here involves slice-saturation slab-inversion vascular space occupancy (SI-SS-VASO) MRI, double echo planar imaging readouts for arterial spin labeling, and VASO in order to correct for BOLD contamination, and a separate BOLD acquisition to minimize inversion effects on the BOLD signal. A standard visual stimulus block design was used to evaluate the spatial and temporal characteristics of CBV-, CBF-, and BOLD-weighted images. ResultsThe high signal-to-noise ratio and spatial resolution of this method leads to robust activation maps. This technique enables the investigation of the differential spatial specificity and temporal characteristics of the different modalities. ConclusionThe pulse sequence could be a powerful tool for studies of neurovascular coupling, hemodynamic response, or calibrated BOLD. Magn Reson Med 74:513-517, 2015.
Original languageEnglish
Pages (from-to)513-517
JournalMagnetic Resonance in Medicine
Issue number2
Publication statusPublished - Aug 2015


  • cerebral blood volume
  • cerebral blood flow
  • BOLD
  • ultra-high field
  • vascular space occupancy
  • VASO
  • functional MRI

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